Clinica Chimica Acta：使用LC-MS/MS方法在女性月经周期、绝经后女性和男性中确定雌二醇参考区间

2019-09-21 gladiator MedSci原创

为了优化医疗决策，需要对不同年龄和性别的雌二醇的参考区间进行考虑。本研究的目的是用一种高精度、可跟踪的<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family

为了优化医疗决策，需要对不同年龄和性别的雌二醇的参考区间进行考虑。本研究的目的是用一种高精度、可跟踪的LC-MS/MS方法建立参考区间，并与文献中的参考区间进行比较。

研究人员对30例健康绝经前妇女月经周期中每日血清雌二醇水平，以及64例男性和33例绝经后妇女血清雌二醇水平进行测量。通过与CDC参考方法的比较，验证了LC-MS/MS方法的准确性。

研究显示LC-MS/MS方法可以与参考方法比较。在早期卵泡期（天-15到-6）雌二醇参考间隔为31-771皮摩尔/ L；在晚卵泡期（天-5〜-1）104-1742皮摩尔/ L; LH峰（第0天）275-2864皮摩尔/ L期间;在早期黄体期（天1至4）95-1188皮摩尔/ L；中期期间黄体期（天5至9）151-1941皮摩尔/ L；晚黄体期（天+10至+14）39-1769皮摩尔/ L。男性的参考间隔为12-136 pmol / L，而绝经后妇女<26皮摩尔/ L。

研究表明，本研究建立的雌二醇参考区间可用于所有可追溯的LC-MS/MS方法。

原始出处：

Sara J.E. Verdonk，Hubert W. Vesper，Estradiol reference intervals in women during the menstrual cycle, postmenopausal women and men using an LC-MS/MS method

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2020-02-05 windight

#CTA#

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2019-09-23 yeye5224612

#绝经#

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2019-09-23 hxzhang

#雌二醇#

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2019-09-23 luwei00

#月经#

59 0
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2019-09-23 chenhongpeng

#绝经后女性#

101 0
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2019-09-23 12498dabm81暂无昵称

#参考区间#

75 0
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2019-09-23 docwu2019

#绝经后#

66 0

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