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Am J Cardiol:CRP升高示易损斑块不稳定性

2014-05-22 高晓方 译 医学论坛网

美国一项研究表明,在C反应蛋白(CRP)水平极高的急性冠脉综合征(ACS)后患者中,非罪犯病变(NCL)相关性严重不良心脏事件发生率较高可能反映了高危NCL更大程度的不稳定性。论文于5月19日在线发表于《美国心脏病学杂志》(Am J Cardiol)。 此项研究共纳入697例接受经皮冠脉介入(PCI)治疗的ACS患者,并对其进行为期3年随访。于患者就诊、1个月和6个月时测定CRP水平,并将其分类

美国一项研究表明,在C反应蛋白(CRP)水平极高的急性冠脉综合征(ACS)后患者中,非罪犯病变(NCL)相关性严重不良心脏事件发生率较高可能反映了高危NCL更大程度的不稳定性。论文于5月19日在线发表于《美国心脏病学杂志》(Am J Cardiol)。【原文下载】




此项研究共纳入697例接受经皮冠脉介入(PCI)治疗的ACS患者,并对其进行为期3年随访。于患者就诊、1个月和6个月时测定CRP水平,并将其分类为正常(<3 mg/L)、升高(3~10 mg/L)或极高(>10 mg/L)三组。评估CRP与NCL的相互作用。

结果显示,各时间点CRP水平升高患者均未伴有更多的高危NCL。然而,与6个月时CRP水平正常者相比,在CRP水平极高患者中未经治疗的高危NCL更有可能导致后续严重不良心脏事件(MACE)。6个月时CRP水平极高患者后续NCL相关性MACE发生率较高(19.0%对7.2%,P=0.039)。

原始出处:

Christopher R. Kelly , Giora Weisz , Akiko Maehara , Gary S. Mintz , Roxana Mehran, Alexandra J. Lansky, Helen Parise , Bernard De Bruyne, Patrick W. Serruys, Gregg W. Stone.Relation of C-Reactive Protein Levels to Instability of Untreated Vulnerable Coronary Plaques (from the PROSPECT study).Am J Cardiol May 19 2014. 【原文下载】


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    2014-06-29 lidage

    炎症与斑块不稳定的相关性又有了新证据

    0

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    2014-06-29 lidage

    炎症与斑块不稳定的相关性又有了新证据

    0

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    2014-05-24 rebeccajiejie
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