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BJH:惰性非霍奇金淋巴瘤幸存者的持续疲劳症状、神经病变和角色功能障碍:一项纵向 PROFILES 登记研究

2022-04-16 网络 网络

在诊断后10年,iNHL患者报告的HRQoL明显低于年龄和性别匹配的正常人群。四分之一至三分之一的患者报告了持续的临床重要症状,如疲劳、神经病变和角色功能障碍

对惰性非霍奇金淋巴瘤 (iNHL) 患者的长期健康相关生活质量 (HRQoL) 和症状持续性知之甚少。因此,这项基于人群的大型纵向研究调查了长期 HRQoL 和症状的持续性,并确定了相关的社会人口、临床和心理因素。

图1:数据采集过程的流程图。惰性非霍奇金淋巴瘤

该研究纳入了在 1999 年至 2014 年之间以及诊断后四个或更多月确诊的患者参加纵向调查。社会人口统计学和临床​​数据来自荷兰癌症登记处。669 名患者完成了 EORTC QLQ-C30 和 CLL-16(74% 的反应率)。患者平均完成四份问卷。

表1:根据癌症类型或正常人群平均(SD)或N(%)得出的患者特征

初始治疗是主动监测(52%)、全身治疗(31%)或放疗(13%)。分别有 36% 的人报告持续疲劳,33% 的持续性神经病变和 25% 的持续性角色功能障碍。这比年龄和性别匹配的标准人群高出 2-3 倍。

图2:(A)疲劳;(B)神经病变;和诊断后10年的(C)角色功能。没有关于正常人群中神经病变的纵向数据。因此,该模型不能绘制出生长曲线。慢性淋巴细胞白血病、FL、滤泡性淋巴瘤、iHL、惰性非霍奇金淋巴瘤、SLL、小淋巴细胞性淋巴瘤

图3:与正常人群相比,持续疲劳、神经病变和角色功能障碍患者的百分比。没有正常人群的纵向神经病变数据,因此该神经病变评分是基于2014年的横断面测量,CLL,慢性淋巴细胞白血病;FL,滤泡性淋巴瘤;iNHL,惰性非霍奇金淋巴瘤;SLL,小淋巴细胞性淋巴瘤

诊断后长达 10 年,评分保持相对稳定,没有临床相关变化。合并症、心理困扰、诊断后时间较短、全身治疗、年龄较小、教育水平和没有伴侣与较差的结果相关(所有p s < 0.05)。多达三分之一的 iNHL 患者会出现长期持续的症状,这些症状不会随着时间的推移而改善。

总之,在诊断后10年,iNHL患者报告的HRQoL明显低于年龄和性别匹配的正常人群。四分之一至三分之一的患者报告了持续的临床重要症状,如疲劳、神经病变和角色功能障碍。研究人员将鼓励临床医生在其疾病的早期阶段与患者讨论症状和日常生活限制,并在可能的情况下将患者转介到适当的支持性治疗中。

 

原始出处:

Ekels, Avan de Poll-Franse, LVPosthuma, EFMKieffer, JIssa, DEKoster, A, et al. Persistent symptoms of fatigue, neuropathy and role-functioning impairment among indolent non-Hodgkin lymphoma survivors: A longitudinal PROFILES registry studyBr J Haematol2022001– 12. https://doi.org/10.1111/bjh.18139

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    2022-07-06 hunizi005
  2. 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    2022-08-31 xfpan12
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    2022-04-18 杨海东

    不断学习

    0

  5. 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    2022-04-16 屋顶瞄爱赏月

    学习了

    0

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    2022-04-16 仁医06
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    2022-04-16 sunylz

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