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JAMA Dermatol:化脓性汗腺炎可增加全因死亡率和主要不良心血管事件的发生(附评论)

2016-02-19 MedSci MedSci原创

JAMA Dermatol:化脓性汗腺炎可增加全因死亡率和主要不良心血管事件的发生化脓性汗腺炎(HS)是一种常见的炎症性皮肤病。已知HS与心血管的(CV)危险因素有关,但是对于HS患者其CV疾病的发生风险尚未清楚。本研究旨在探究HS患者其CV疾病的发生风险。采用以人群为基础的队列研究,时间为1997年1月1日至2011年12月31日。在35368名丹麦人研究人群中,5964名HS患者年龄在18岁或

化脓性汗腺炎(HS)是一种常见的炎症性皮肤病。已知HS与心血管的(CV)危险因素有关,但是对于HS患者其CV疾病的发生风险尚未清楚。本研究旨在探究HS患者其CV疾病的发生风险。

采用以人群为基础的队列研究,时间为1997年1月1日至2011年12月31日。在35368名丹麦人研究人群中,5964名HS患者年龄在18岁或以上,按1:5设置29404名对照人群,匹配了年龄,性别及时间。

研究结果为心肌梗死(MI)、中风、CV相关死亡,主要不良CV事件(MACE),和全因死亡率。使用泊松回归估计发病率比(IRRs)。

5964名患者的平均年龄为37.7岁,其中4346名为女性。随访期间共发生了62例MIs,74例缺血性中风,63例CV相关的死亡,169例MACEs,231例全因死亡病例。校正(年龄、性别、社会经济状况、吸烟、合并症和药物)后,MI的IRRs为1.57,缺血性卒中的IRRs为1.33,CV相关死亡的IRRs为1.95,MACEs的IRRs为1.53,全因死亡率的IRRs为1.35。重症牛皮癣患者作为对照者时,HS患者校正后MI的IRRs分别1,缺血性卒中的IRRs为0.93,CV相关死亡的IRRs为1.58,MACEs的IRRs为1.08,全因死亡率的IRRs为1.09。

化脓性汗腺炎作为一个独立的危险因素可明显增加不良CV事件的发生风险,并可增加全因死亡率。HS患者的CV相关死亡率高于重症银屑病患者。该研究结果呼吁公众提高对此关联的认识,并应对此临床结果进行更多的研究。


编辑按:

以心血管疾病,肿瘤为主的慢性疾病是死亡的最重要的因素之一。而其它疾病引发的死亡,也往往与此有关。例如糖尿病,以往关心血糖是否达标,后来关心糖尿病相关并发症,而近些年则更关心糖尿病的心血管风险;类似其它疾病也相似。哪怕这里报道的化脓性汗腺炎,这种“小病”背后可能蕴含着大问题——心血管的风险。

当然,我们仍然要进一步思考,它们之间的关联性。化脓性汗腺炎背后是感染,或者说是免疫功能相对下降,或者说是皮肤粘膜屏障功能减退,这是几种可能的假设。而这些机制背后,关联的可能是心血管斑块形成,斑块的稳定性,血管内皮的完整性,这是否是最终导致心血管相关的死亡风险增加的原因?这是值得探讨的科学问题。

原始出处:

Alexander Egeberg, Gunnar. H. Gislason, Peter R. Hansen. Risk of Major Adverse Cardiovascular Events and All-Cause Mortality in Patients With Hidradenitis Suppurativa. JAMA Dermatol. Published online February 17, 2016. doi:10.1001/jamadermatol.2015.6264

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    2017-11-03 天地飞扬

    谢谢分享!

    0

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    2016-03-17 任然

    值得学习的

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=258244, encodeId=0e1725824477, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Nov 03 06:41:19 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748156, encodeId=e6da1e481567b, content=<a href='/topic/show?id=129533595e9' target=_blank style='color:#2F92EE;'>#化脓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33595, encryptionId=129533595e9, topicName=化脓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443536086917, createdName=hb2020ye, createdTime=Sun Aug 14 08:29:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643398, encodeId=fce01643398d3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Wed Apr 06 15:29:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=70132, encodeId=2f98e0132b3, content=值得学习的, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Thu Mar 17 13:21:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65103, encodeId=01a165103b8, content=赞小编?, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Sun Feb 21 22:42:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65104, encodeId=80936510423, content=赞小编!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Sun Feb 21 22:42:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251459, encodeId=e277125145929, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sun Feb 21 13:29:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533194, encodeId=6d091533194a5, content=<a href='/topic/show?id=c7a02326657' target=_blank style='color:#2F92EE;'>#主要不良心血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23266, encryptionId=c7a02326657, topicName=主要不良心血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=929a12392280, createdName=wetgdt, createdTime=Sun Feb 21 13:29:00 CST 2016, time=2016-02-21, status=1, ipAttribution=)]
    2016-02-21 180****7709(上善若水)

    赞小编?

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=258244, encodeId=0e1725824477, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Nov 03 06:41:19 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748156, encodeId=e6da1e481567b, content=<a href='/topic/show?id=129533595e9' target=_blank style='color:#2F92EE;'>#化脓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33595, encryptionId=129533595e9, topicName=化脓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443536086917, createdName=hb2020ye, createdTime=Sun Aug 14 08:29:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643398, encodeId=fce01643398d3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Wed Apr 06 15:29:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=70132, encodeId=2f98e0132b3, content=值得学习的, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Thu Mar 17 13:21:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65103, encodeId=01a165103b8, content=赞小编?, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Sun Feb 21 22:42:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65104, encodeId=80936510423, content=赞小编!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Sun Feb 21 22:42:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251459, encodeId=e277125145929, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sun Feb 21 13:29:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533194, encodeId=6d091533194a5, content=<a href='/topic/show?id=c7a02326657' target=_blank style='color:#2F92EE;'>#主要不良心血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23266, encryptionId=c7a02326657, topicName=主要不良心血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=929a12392280, createdName=wetgdt, createdTime=Sun Feb 21 13:29:00 CST 2016, time=2016-02-21, status=1, ipAttribution=)]
    2016-02-21 180****7709(上善若水)

    赞小编!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=258244, encodeId=0e1725824477, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Nov 03 06:41:19 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748156, encodeId=e6da1e481567b, content=<a href='/topic/show?id=129533595e9' target=_blank style='color:#2F92EE;'>#化脓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33595, encryptionId=129533595e9, topicName=化脓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443536086917, createdName=hb2020ye, createdTime=Sun Aug 14 08:29:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643398, encodeId=fce01643398d3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Wed Apr 06 15:29:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=70132, encodeId=2f98e0132b3, content=值得学习的, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Thu Mar 17 13:21:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65103, encodeId=01a165103b8, content=赞小编?, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Sun Feb 21 22:42:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65104, encodeId=80936510423, content=赞小编!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Sun Feb 21 22:42:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251459, encodeId=e277125145929, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sun Feb 21 13:29:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533194, encodeId=6d091533194a5, content=<a href='/topic/show?id=c7a02326657' target=_blank style='color:#2F92EE;'>#主要不良心血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23266, encryptionId=c7a02326657, topicName=主要不良心血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=929a12392280, createdName=wetgdt, createdTime=Sun Feb 21 13:29:00 CST 2016, time=2016-02-21, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=258244, encodeId=0e1725824477, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Nov 03 06:41:19 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748156, encodeId=e6da1e481567b, content=<a href='/topic/show?id=129533595e9' target=_blank style='color:#2F92EE;'>#化脓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33595, encryptionId=129533595e9, topicName=化脓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443536086917, createdName=hb2020ye, createdTime=Sun Aug 14 08:29:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643398, encodeId=fce01643398d3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Wed Apr 06 15:29:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=70132, encodeId=2f98e0132b3, content=值得学习的, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Thu Mar 17 13:21:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65103, encodeId=01a165103b8, content=赞小编?, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Sun Feb 21 22:42:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65104, encodeId=80936510423, content=赞小编!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Sun Feb 21 22:42:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251459, encodeId=e277125145929, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sun Feb 21 13:29:00 CST 2016, time=2016-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533194, encodeId=6d091533194a5, content=<a href='/topic/show?id=c7a02326657' target=_blank style='color:#2F92EE;'>#主要不良心血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23266, encryptionId=c7a02326657, topicName=主要不良心血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=929a12392280, createdName=wetgdt, createdTime=Sun Feb 21 13:29:00 CST 2016, time=2016-02-21, status=1, ipAttribution=)]
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