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NSCLC中抗血管新生治疗(AAT)的进展与瓶颈

2011-10-16 MedSci原创 MedSci原创

     Wolfgang Hilbe教授   9月3-4日,第3届中德肺癌论坛在上海举行。在为期两天的论坛中,数十位国内外知名肺癌专家对2011年全球肺癌领域的学术热点、难点进行年度盘点,并和与会人士展开全面的交流和讨论。   奥地利茵斯布鲁克(Innsbruck)医科大学Wolfgang Hilbe教授报告了抗血管生成治疗(AAT)的进展与面临的问题。   ECOG

     Wolfgang Hilbe教授   9月3-4日,第3届中德肺癌论坛在上海举行。在为期两天的论坛中,数十位国内外知名肺癌专家对2011年全球肺癌领域的学术热点、难点进行年度盘点,并和与会人士展开全面的交流和讨论。   奥地利茵斯布鲁克(Innsbruck)医科大学Wolfgang Hilbe教授报告了抗血管生成治疗(AAT)的进展与面临的问题。   ECOG 4599研究是一项贝伐珠单抗联合化疗治疗NSCLC的III期临床研究。贝伐珠单抗联合化疗可显著改善各项研究终点。而AVAIL研究显示,贝伐珠单抗联合化疗组,无进展生存期(PFS)有延长,但总生存期(OS)无改善。   ESCAPE研究是一项紫杉醇+卡铂单独或与索拉非尼联合治疗晚期NSCLC的III期临床研究。受试者为不可手术的IIIB或IV期初治 NSCLC,ECOG PS 评分0或1分,共926入选,一组接受紫杉醇(200 mg/m2,第1天),卡铂(AUC 6 mg/ml/min,第1 天),每3周为一周期,最多6个周期的化疗。另一组在

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1071855, encodeId=710f10e1855a3, content=学习学习使我快乐学习也最学习学习学习学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Fri Nov 19 19:31:39 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932946, encodeId=b390193294635, content=<a href='/topic/show?id=6b1255e66ba' target=_blank style='color:#2F92EE;'>#抗血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55766, encryptionId=6b1255e66ba, topicName=抗血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat Jun 16 02:29:00 CST 2012, time=2012-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4346, encodeId=aeec4346ec, content=You have more usfeul info than the British had colonies pre-WWII., beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=maria, createdTime=Sun Jun 03 17:44:00 CST 2012, time=2012-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740384, encodeId=b8511e403845a, content=<a href='/topic/show?id=5996896e011' target=_blank style='color:#2F92EE;'>#血管新生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89670, encryptionId=5996896e011, topicName=血管新生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=093634755022, createdName=ms1467340776200723, createdTime=Mon Jul 02 13:29:00 CST 2012, time=2012-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3541, encodeId=75ac3541bc, content=精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Oct 31 21:42:00 CST 2011, time=2011-10-31, status=1, ipAttribution=)]
    2021-11-19 ms5000000518166734

    学习学习使我快乐学习也最学习学习学习学习学习学习学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1071855, encodeId=710f10e1855a3, content=学习学习使我快乐学习也最学习学习学习学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Fri Nov 19 19:31:39 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932946, encodeId=b390193294635, content=<a href='/topic/show?id=6b1255e66ba' target=_blank style='color:#2F92EE;'>#抗血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55766, encryptionId=6b1255e66ba, topicName=抗血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat Jun 16 02:29:00 CST 2012, time=2012-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4346, encodeId=aeec4346ec, content=You have more usfeul info than the British had colonies pre-WWII., beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=maria, createdTime=Sun Jun 03 17:44:00 CST 2012, time=2012-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740384, encodeId=b8511e403845a, content=<a href='/topic/show?id=5996896e011' target=_blank style='color:#2F92EE;'>#血管新生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89670, encryptionId=5996896e011, topicName=血管新生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=093634755022, createdName=ms1467340776200723, createdTime=Mon Jul 02 13:29:00 CST 2012, time=2012-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3541, encodeId=75ac3541bc, content=精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Oct 31 21:42:00 CST 2011, time=2011-10-31, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1071855, encodeId=710f10e1855a3, content=学习学习使我快乐学习也最学习学习学习学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Fri Nov 19 19:31:39 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932946, encodeId=b390193294635, content=<a href='/topic/show?id=6b1255e66ba' target=_blank style='color:#2F92EE;'>#抗血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55766, encryptionId=6b1255e66ba, topicName=抗血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat Jun 16 02:29:00 CST 2012, time=2012-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4346, encodeId=aeec4346ec, content=You have more usfeul info than the British had colonies pre-WWII., beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=maria, createdTime=Sun Jun 03 17:44:00 CST 2012, time=2012-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740384, encodeId=b8511e403845a, content=<a href='/topic/show?id=5996896e011' target=_blank style='color:#2F92EE;'>#血管新生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89670, encryptionId=5996896e011, topicName=血管新生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=093634755022, createdName=ms1467340776200723, createdTime=Mon Jul 02 13:29:00 CST 2012, time=2012-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3541, encodeId=75ac3541bc, content=精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Oct 31 21:42:00 CST 2011, time=2011-10-31, status=1, ipAttribution=)]
    2012-06-03 maria

    You have more usfeul info than the British had colonies pre-WWII.

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1071855, encodeId=710f10e1855a3, content=学习学习使我快乐学习也最学习学习学习学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Fri Nov 19 19:31:39 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932946, encodeId=b390193294635, content=<a href='/topic/show?id=6b1255e66ba' target=_blank style='color:#2F92EE;'>#抗血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55766, encryptionId=6b1255e66ba, topicName=抗血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat Jun 16 02:29:00 CST 2012, time=2012-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4346, encodeId=aeec4346ec, content=You have more usfeul info than the British had colonies pre-WWII., beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=maria, createdTime=Sun Jun 03 17:44:00 CST 2012, time=2012-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740384, encodeId=b8511e403845a, content=<a href='/topic/show?id=5996896e011' target=_blank style='color:#2F92EE;'>#血管新生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89670, encryptionId=5996896e011, topicName=血管新生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=093634755022, createdName=ms1467340776200723, createdTime=Mon Jul 02 13:29:00 CST 2012, time=2012-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3541, encodeId=75ac3541bc, content=精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Oct 31 21:42:00 CST 2011, time=2011-10-31, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1071855, encodeId=710f10e1855a3, content=学习学习使我快乐学习也最学习学习学习学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Fri Nov 19 19:31:39 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932946, encodeId=b390193294635, content=<a href='/topic/show?id=6b1255e66ba' target=_blank style='color:#2F92EE;'>#抗血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55766, encryptionId=6b1255e66ba, topicName=抗血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat Jun 16 02:29:00 CST 2012, time=2012-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4346, encodeId=aeec4346ec, content=You have more usfeul info than the British had colonies pre-WWII., beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=maria, createdTime=Sun Jun 03 17:44:00 CST 2012, time=2012-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740384, encodeId=b8511e403845a, content=<a href='/topic/show?id=5996896e011' target=_blank style='color:#2F92EE;'>#血管新生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89670, encryptionId=5996896e011, topicName=血管新生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=093634755022, createdName=ms1467340776200723, createdTime=Mon Jul 02 13:29:00 CST 2012, time=2012-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3541, encodeId=75ac3541bc, content=精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Oct 31 21:42:00 CST 2011, time=2011-10-31, status=1, ipAttribution=)]
    2011-10-31 lovetcm

    精彩

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