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Stroke:颈动脉颅内段钙化与接受机械取栓患者的血运重建有关吗?

2016-12-24 haofan MedSci原创

在急性脑卒中患者在机械取栓前较大量的颈动脉颅内段钙化是糟糕的术后动脉血运重建和较差的功能预后的一个指标。

颈动脉颅内段钙化是颅内动脉硬化的标志,可能影响接受机械取栓的急性脑卒中患者的血运重建和临床预后。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,旨在评估颈动脉颅内段钙化与接受机械取栓的急性脑卒中患者的血运重建和临床预后之间的相关性。

研究人员纳入了194例在2009年1月至2015年9月期间在卒中单元住院并接受机械取栓的前循环闭塞患者。颈动脉颅内段钙化通过机械取栓前双侧颅内颈动脉的非增强CT扫描来进行定性分析。完全动脉血运重建是指最后的影像学检查脑梗塞≥2b的患者进行溶栓治疗。不良功能预后是指90天改良的Rankin评分>2分。研究人员运用调整了混杂因素的Logistic回归模型评估了颈动脉颅内段钙化体积对完全动脉血运重建、功能预后和死亡率的独立影响。

研究人员发现164例(84.5%)患者发生了颈动脉颅内段钙化,其平均体积为87.1mm3(第25-75位数为:18.9-254.6 mm3)。研究者发现,增大的颈动脉颅内段钙化体积与不完全动脉血运重建(转化的颈动脉颅内段钙化体积每增加一个单位的调整后比值比为0.73[95%可信区间为0.57-0.93])和不良的功能预后(转化的颈动脉颅内段钙化体积每增加一个单位的调整后比值比为1.31[95%可信区间为1.04-1.66])相关。

由此可见,在急性脑卒中患者在机械取栓前较大量的颈动脉颅内段钙化是糟糕的术后动脉血运重建和较差的功能预后的一个指标。  

原始出处:


María Hernández-Pérez, et al. Intracranial Carotid Artery Calcification Relates to Recanalization and Clinical Outcome After Mechanical Thrombectomy. Stroke. 2016. 

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    2016-12-25 Lisa971

    血管的管理,是很多疾病的预防的关键

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