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DDS:不同消化道肿瘤的患者粪便微生物组成也不同

2018-11-19 MedSci MedSci原创

我们都知道,栖息在人体肠道中的微生物生态系统构成了我们生理和新陈代谢的核心组成部分,它们参与着我们人体的健康和疾病的状态的改变。不同肠道微生物群的组成和活性的变化可导致免疫力下降,炎症的出现,甚至癌症的发生。因此,本项研究基于胃肠道肿瘤部位(GIT)比较来自不同位置的肿瘤的患者的粪便样品中肠道微生物群的组成和多样性,并评估细菌组合物对肿瘤发生的可能影响。

背景
我们都知道,栖息在人体肠道中的微生物生态系统构成了我们生理和新陈代谢的核心组成部分,它们参与着我们人体的健康和疾病的状态的改变。不同肠道微生物群的组成和活性的变化可导致免疫力下降,炎症的出现,甚至癌症的发生。因此,本项研究基于肠道肿瘤部位(GIT)比较来自不同位置的肿瘤的患者的粪便样品中肠道微生物群的组成和多样性,并评估细菌组合物对肿瘤发生的可能影响。

方法
研究人员通过16SRNA基因测序对肠道微生物群进行分析,这些基因测序的样本来自83名被诊断患有不同肠道肿瘤的患者的粪便,以及13名健康个体的粪便。

结果
与健康个体相比,胃肿瘤患者的粪便中肠杆菌科水平升高,而直肠肿瘤患者粪便中的双歧杆菌水平较低。在患有结肠肿瘤的患者中观察到较低的乳杆菌科的丰度,在癌症治疗后取样的GIT患者的粪便中乳酸杆菌的丰度更高。除了位点特异性差异外,患有肿瘤的患者中都存在高丰度瘤胃球菌及Subdoligranulum菌和低丰度的Lachnoclostridium和Oscillibacter菌。

结论
本项研究表明,肠道微生物群的变化随着GIT肿瘤的位置不同而有所差异。Lactobacillaceae和Bifidobacteriaceae菌的丰度在肿瘤患者中都较低,肠杆菌科丰度的增加可以提示肠道健康受损。

原始出处:

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    2018-11-21 Homburg
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