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CIRC RES:iPSCs胞外囊泡修复心肌更加有效和安全

2017-11-09 MedSci MedSci原创

心血管iPSCs胞外囊泡
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细胞外囊泡（EVs）是细胞以出芽方式或者外分泌方式形成的一种膜状小体。由诱导多能干细胞（iPSCs）分泌的EVs产生的心肌修复能力与iPSCs直接相比是否存在优势尚未阐明。本研究的目的旨在评估iPSCs分泌的Evs在体外对心肌细胞生物学功能的影响，以及通过体内实验比较iPSCs与iPSCs分泌的EVs在心肌修复能力上的差异。本研究通过连续离心的方法对小鼠的iPSCs的Evs进行提取，通过原子力显微

细胞外囊泡（EVs）是细胞以出芽方式或者外分泌方式形成的一种膜状小体。由诱导多能干细胞（iPSCs）分泌的EVs产生的心肌修复能力与iPSCs直接相比是否存在优势尚未阐明。本研究的目的旨在评估iPSCs分泌的Evs在体外对心肌细胞生物学功能的影响，以及通过体内实验比较iPSCs与iPSCs分泌的EVs在心肌修复能力上的差异。本研究通过连续离心的方法对小鼠的iPSCs的Evs进行提取，通过原子力显微镜、高分辨率的流式细胞仪、实时荧光定量PCR和质谱方法对EVs的形态和内容进行评估。iPSC-EVs富含miRNA与促血管生成和细胞保护作用的蛋白质，有促进心脏内皮细胞血管新生、迁移和抗凋亡的作用。在心梗小鼠再灌注后48h模型中，将囊泡、iPSCs和iPSC-EVs注射入心肌中，与囊泡注射小鼠相比，iPSCs和iPSC-EVs注射的小鼠心梗后35天的左室功能更佳，其中iPSC-EVs注射的小鼠最佳。iPSC-EVs注射的小鼠的左室质量也更低，梗塞区域的灌注功能更佳，细胞凋亡更少。此外，iPSCs注射会引起畸胎瘤的发生，而iPSC-EVs则不会。研究结果表明，相比于诱导多能干细胞，其分泌的胞外囊

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    2017-11-11 chengjn

    #iPS#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1377755, encodeId=bccf13e7755c1, content=<a href='/topic/show?id=17b810004ce' target=_blank style='color:#2F92EE;'>#iPS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10004, encryptionId=17b810004ce, topicName=iPS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Sat Nov 11 10:16:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404283, encodeId=068b140428338, content=<a href='/topic/show?id=6cfd14e93a0' target=_blank style='color:#2F92EE;'>#PSC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14793, encryptionId=6cfd14e93a0, topicName=PSC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b62453284, createdName=gjsgj, createdTime=Sat Nov 11 10:16:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448787, encodeId=29ab1448e8724, content=<a href='/topic/show?id=c6dd1000849' target=_blank style='color:#2F92EE;'>#iPSCs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10008, encryptionId=c6dd1000849, topicName=iPSCs)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201103/27ddabe24d5c43739f1308f83d97be8c/4e3d31f92c9f4025bcf1d53b255ca4e5.jpg, createdBy=ffb85431490, createdName=caoliehu, createdTime=Sat Nov 11 10:16:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538818, encodeId=04ff15388181a, content=<a href='/topic/show?id=60de100065b' target=_blank style='color:#2F92EE;'>#iPSC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10006, encryptionId=60de100065b, topicName=iPSC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37d013060412, createdName=neurosurgeon, createdTime=Sat Nov 11 10:16:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599822, encodeId=a19d159982200, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Sat Nov 11 10:16:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260096, encodeId=6a2c26009661, content=细胞外囊泡(EVs)是细胞以出芽方式或者外分泌方式形成的一种膜状小体.由诱导多能干细胞(iPSCs)分泌的EVs产生的心肌修复能力与iPSCs直接相比是否存在优势尚未阐明., beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Nov 09 22:30:36 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260072, encodeId=94fd2600e2df, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Nov 09 21:13:12 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260065, encodeId=2b75260065cb, content=学习了.非常好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Thu Nov 09 20:26:02 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-11 gjsgj

    #PSC#

    0

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    2017-11-11 caoliehu

    #iPSCs#

    0

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    2017-11-11 neurosurgeon

    #iPSC#

    0

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    2017-11-11 charl1234573

    #囊泡#

    0

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    2017-11-09 有备才能无患

    细胞外囊泡(EVs)是细胞以出芽方式或者外分泌方式形成的一种膜状小体.由诱导多能干细胞(iPSCs)分泌的EVs产生的心肌修复能力与iPSCs直接相比是否存在优势尚未阐明.

    0

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    2017-11-09 changjiu

    学习一下谢谢

    0

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    2017-11-09 天涯183

    学习了.非常好的文章

    0

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