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JAMA Neurol:30岁时心血管危险因素多,老年痴呆风险高!

2019-11-07 岱西 中国循环杂志

近日,发表在JAMA Neurol上的一项英国研究提醒:30多岁不注意心血管风险,就开始影响大脑健康了,而且这种年轻时对心脑健康的影响更甚于50岁后。

近日,发表在JAMA Neurol上的一项英国研究提醒:30多岁不注意心血管风险,就开始影响大脑健康了,而且这种年轻时对心脑健康的影响更甚于50岁后。

研究显示,血管风险随年龄增长而增加,36岁时2.7%,69岁则达24.3%。但老中青人群中,血管风险高都与70岁时脑容量小、白质高信号更强有关。

而白质高信号区域多易受缺血影响,白质高信号多为脑小血管病变的特征性影像学表现。

进一步分析发现,36岁时血管风险,与70岁时脑部健康更相关,血管风险评分每增加1%,70岁时白质高信号增加9%,脑容量减少3.6 ml。

而53岁时,血管风险评分每增加1%,白质高信号增加2%,脑容量减少0.8 ml;69岁时,血管风险评分每增加1%,白质高信号增加1%,脑容量减少0.6 ml。

值得注意的是,36岁时这种心血管风险对大脑健康的影响对女性更为显著。同期述评专家指出,这或者某种程度上解释了老年女性痴呆症风险更高的原因。

不过研究未发现,血管风险与β淀粉样蛋白的相关性。

研究者指出,他们的研究提示,从生命早期就应注重心血管健康,以更有效预防老年痴呆的发生。此外,也提示对于淀粉样蛋白沉积这一痴呆症的发病机制假说外,还应注意其他可能的因素和途径。

这项研究共评估了Insight 46队列中502人,51%为男性。受试者在36岁、53岁和69岁时,分别接受了Framingham心脏研究-心血管风险评分的评估,70岁时又接受了认知功能和脑部影像学等检查。

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    2020-08-09 yinhl1978
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    2019-11-08 junJUN

    老年人痴呆何药可用??

    0

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