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Neurology:未确定来源的栓塞性卒中患者颈动脉斑块与房颤

2019-05-09 xing.T 网络

由此可见,相比于颈动脉粥样硬化斑块的患者,非典型颈动脉斑块的ESUS患者AF检出率较低。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,该研究旨在调查未确定来源(ESUS)栓塞性卒中患者随访期间同侧颈动脉斑块与房颤(AF)检出率之间的关系。

研究人员汇总了来自3个前瞻性卒中登记的所有连续就诊的ESUS患者数据。多变量逐步回归评估非颈动脉颈动脉斑块与AF检测之间的关联。通过Kaplan-Meier检验估计AF的10年累积概率。 

在777例患者中随访2642人次每年,341例(38.6%)患者患有同侧非颈动脉斑块。在随访期间,总人群中112名(14.4%)患者检测到AF。非颈动脉斑块患者(每100患者每年2.9%)的AF检出总率为8.5%,无斑块患者(每100患者每年5.0%)的AF检出率为19.0%(未调整风险比[HR]为0.56,95%置信区间[CI]为0.37-0.84)。同侧非颈动脉斑块的存在与AF检测的可能性较低相关(校正HR为0.57,95%CI为0.34-0.96,p=0.03)。同侧非颈动脉粥样硬化斑块患者的AF检测的10年累积概率低于无斑块患者(34.5%,95%CI为21.8-47.2 vs. 49.0%,95%CI为40.4-57.6,对数秩检验:11.8,p=0.001)。 

由此可见,相比于颈动脉粥样硬化斑块的患者,非典型颈动脉斑块的ESUS患者AF检出率较低。 

原始出处:

George Ntaios,et al.Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source.Neurology.2019.https://doi.org/10.1212/WNL.0000000000007611

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    2020-03-19 yinhl1978
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    2019-05-09 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

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