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J Thromb Haemost:COVID-19患者血小板减少症与死亡率的关系

2020-04-18 MedSci原创 MedSci原创

血小板减少症在COVID-19患者中很常见,并且与院内死亡风险增加相关。COVID-19患者血小板数越少,死亡率越高。

严重急性呼吸综合症冠状病毒2(SARS-CoV-2)引起的急性冠状病毒病2019(COVID-19)在世界范围内迅速传播。COVID-19患者血小板减少症尚未得到充分分析。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,该研究旨在描述COVID-19患者血小板减少症情况。

研究人员回顾性地收集了武汉市金银潭医院1476例连续就诊的COVID‐19患者住院期间的最低血小板计数,并将其分为(0-50]、(50-100]、(100‐150]或(150‐)×109/L)组,研究人员分析了最低点血小板计数和院内死亡率。

在所有患者中,238名(16.1%)患者血小板数量减少,306名(20.7%)患有血小板减少症。与幸存者相比,非幸存者年龄更大,血小板减少症的发生率更低,最低血小板计数也更低。(0-50]、(50-100]、(100-150]和(150-)组患者的院内死亡率分别为92.1%、61.2%、17.5%和4.7%。以(150-)组为对照,最低血小板计数为(100-150]、(50-100]和(0-50]的患者相对风险分别为3.42(95%CI为2.36-4.96)、9.99(95%CI为7.16-13.94)和13.68(95%CI为9.89-18.92)。

由此可见,血小板减少症在COVID-19患者中很常见,并且与院内死亡风险增加相关。COVID-19患者血小板数越少,死亡率越高。

原始出处:

Xiaobo Yang.et al.Thrombocytopenia and Its Association with Mortality in Patients with COVID‐19.Journal of Thrombosis and Haemostasis.2020.https://onlinelibrary.wiley.com/doi/10.1111/jth.14848

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