Baidu
map

Hypertension:钠饮食摄入与肾钠处理功能的相互作用可影响血压

2013-09-03 佚名 丁香园

图1.不同的锂排泄分数三分位组中,夜间舒张压与钠排泄的关系。 图2.夜间收缩压与钠饮食摄入与肾钠处理功能的相互作用的关系。 研究要点: 钠饮食摄入和近端肾小管的钠处理功能相互作用,从而影响血压水平。 低钠饮食对于控制血压及降低肾功损害都有着长远的益处。 大量的研究指出钠摄入量与血压水平相关,但是,这种相关度在个体之间存在明显的差异,且多种因素可影响两者的相关性强度。为此,


图1.不同的锂排泄分数三分位组中,夜间舒张压与钠排泄的关系。


图2.夜间收缩压与钠饮食摄入与肾钠处理功能的相互作用的关系。

研究要点:

钠饮食摄入和近端肾小管的钠处理功能相互作用,从而影响血压水平。

低钠饮食对于控制血压及降低肾功损害都有着长远的益处。

大量的研究指出钠摄入量与血压水平相关,但是,这种相关度在个体之间存在明显的差异,且多种因素可影响两者的相关性强度。为此,来自上海交通大学瑞金医院王继光等从钠饮食摄入与肾钠处理功能的关系为研究点进行了相关临床试验,研究发现钠饮食摄入与肾钠处理功能的相互作用可影响血压。该研究论文发表于8月Hypertension杂志。【原文下载

研究人员选取了766名受检者,其中男性379名,动态血压异常患者478名;有697名受检者从未接受过降压药物治疗,69名超过两周未接受降压药物治疗。研究测量了24小时尿钠排泄及内源锂清除率来分别评估钠饮食摄入与肾钠处理功能,同时,研究者测量了锂排泄分数及远端的钠重吸收率分别作为近端和远端的肾钠处理功能参数。

调整处理后统计结果显示尿钠排泄,锂排泄分数及远端钠重吸收分数等因素与临床或动态血压水平并没有明显的相关性;但是,在夜间舒张血压方面,尿钠排泄和锂排泄分数有明显的相互影响作用。除去锂排泄分数三分位组的1号组,在其余两组,夜间舒张血压与尿钠排泄成正相关;然而,锂排泄分数1号组的夜间舒张血压水平要明显高于3号组,而且在钠排泄分数的最低组更为明显。在夜间收缩血压,临床或动态24小时血压方面也有相似的趋势。

王继光等人认为该研究指出了钠饮食摄入和近端肾小管的钠处理功能相互作用,从而影响血压水平。低钠饮食对于控制血压及降低肾功损害都有着长远的益处。

原文下载

Zou J, Li Y, Yan CH, Wei FF, Zhang L, Wang JG.Blood Pressure in Relation to Interactions Between Sodium Dietary Intake and Renal Handling.Hypertension. 2013 Aug 19.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2038469, encodeId=a23a2038469a5, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Apr 22 07:41:00 CST 2014, time=2014-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909168, encodeId=a630190916899, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jan 13 14:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725530, encodeId=5a4b1e2553098, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 01 21:41:00 CST 2014, time=2014-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471491, encodeId=387314e1491b6, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501024, encodeId=70031501024cb, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2038469, encodeId=a23a2038469a5, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Apr 22 07:41:00 CST 2014, time=2014-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909168, encodeId=a630190916899, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jan 13 14:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725530, encodeId=5a4b1e2553098, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 01 21:41:00 CST 2014, time=2014-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471491, encodeId=387314e1491b6, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501024, encodeId=70031501024cb, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2038469, encodeId=a23a2038469a5, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Apr 22 07:41:00 CST 2014, time=2014-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909168, encodeId=a630190916899, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jan 13 14:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725530, encodeId=5a4b1e2553098, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 01 21:41:00 CST 2014, time=2014-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471491, encodeId=387314e1491b6, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501024, encodeId=70031501024cb, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=)]
    2014-05-01 feather89
  4. [GetPortalCommentsPageByObjectIdResponse(id=2038469, encodeId=a23a2038469a5, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Apr 22 07:41:00 CST 2014, time=2014-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909168, encodeId=a630190916899, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jan 13 14:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725530, encodeId=5a4b1e2553098, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 01 21:41:00 CST 2014, time=2014-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471491, encodeId=387314e1491b6, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501024, encodeId=70031501024cb, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=)]
    2013-09-05 ylz8405
  5. [GetPortalCommentsPageByObjectIdResponse(id=2038469, encodeId=a23a2038469a5, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Apr 22 07:41:00 CST 2014, time=2014-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909168, encodeId=a630190916899, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jan 13 14:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725530, encodeId=5a4b1e2553098, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 01 21:41:00 CST 2014, time=2014-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471491, encodeId=387314e1491b6, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501024, encodeId=70031501024cb, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Sep 05 05:41:00 CST 2013, time=2013-09-05, status=1, ipAttribution=)]

相关资讯

Kidney INT:血液透析后 血压下降与生存率呈U形相关

美国和韩国联合研究表明,血液透析后血压(BP)适度下降与最大生存率相关,而血压上升或大幅下降与生存率降低相关。 研究纳入113255例接受血液透析者,评估血液透析期间BP变化和死亡率的相关性。使用考克斯回归模型进行分析。 结果为,患者平均年龄为61岁,45%为女性,32%为非裔美国人,58%为糖尿病患者。中位随访时间为2.2年,共死亡53461(47.2%)例。透析后收缩压降低0~30 mmH

JAMA:舒张压较低与脑萎缩进展较快相关

荷兰一项研究表明,在伴有动脉疾病表现的患者中,基线舒张压较低与脑皮质下萎缩进展较快具有相关性,并且与随访期间的血压进程无关。论文6月10日在线发表于《美国医学会 神经病学》杂志(JAMA Neurol)。 此项前瞻性研究共纳入663例伴有冠脉疾病、脑血管病、周围动脉病或腹主动脉瘤的患者(平均年龄57岁)。利用基线和随访时自动分段对脑实质分数、皮层灰质分数和脑室分数进行定量,以判断整体、

Lancet:新发腔隙性脑梗患者收缩压应控制在130mmHg以下(SPS3 研究)

对于预防脑卒中复发而言,目前尚不清楚什么样的血压目标是最佳水平。为此,SPS3研究组设计了相关研究了解对于腔隙性脑梗患者而言,不同血压水平对脑卒中复发的影响,研究结果发表在The Lancet 杂志上。 本研究所纳入的受试者居住在北美、拉丁美洲和西班牙,并且近期发生腔隙性脑梗。研究者入组受试者的时间为2003年3月至2011年4月,根据2*2的多因素设计,研究者将符合入组标准的受试者随机

JAMA:家庭血压远程监控可改善血压控制

《美国医学会杂志》2013年7月3日在线发表的一则研究显示,与常规治疗相比,纳入家庭血压(BP)远程监控(由药剂师管理)策略的一种干预治疗可改善血压控制,并在12个月的干预时间里导致患者血压下降,患者血压的改善维持至干预之后的第6个月。“高血压是患者就诊于初级保健医生的最常见的慢性疾病,该疾病影响着美国30%的成年人;据估计每年在高血压上所花费的费用要超过500亿美元。几十年的研究显示,治疗高血压

JAMA:远程监控的干预有助于更好地改善和保持血压

据7月3日发表在JAMA(《美国医学会杂志》)上的一则研究披露,与常规治疗相比,由药剂师进行管理的居家血压(BP)远程监控组成的一种干预治疗在12个月的时间段内达到了改善血压控制和血压下降的效果,并且在该干预之后血压的改善维持了6个月的时间。 根据文章的背景资料:“高血压是最常见的慢性疾病,病人会因为该疾病病而到初级保健医生处就诊;该疾病对美国30%的成年人造成影响;据估计每年在高血压上所花费的

Ann Intern Med:严格控制血压对老年慢性肾病患者可能有害

一项针对美国退伍军人的大型全国队列研究显示,在非透析依赖性慢性肾病患者中,收缩压和舒张压较低者的死亡率确实更低,但是一旦舒张压低于70 mmHg,这一关联就不复存在了。该研究结果发表在《内科学年鉴》上[Ann Intern Med. 2013;159(4):233-242]。不仅如此,主要研究者、孟菲斯退伍军人事务部医疗中心肾病科主任Csaba P. Kovesdy医生指出,具有“理想”血压值(低

Baidu
map
Baidu
map
Baidu
map