转化医学

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竞争性内源RNA（ceRNA）数据库资源集锦

2015-12-03 MedSci MedSci原创

上海中山医院医生/ 主任医师

ceRNA（competing endogenous RNAs，竞争性内源RNA）假说揭示了一种RNA间相互作用的新机制。已知microRNA可以通过结合mRNA导致基因沉默，而ceRNA可以通过竞争性地结合microRNA来调节基因表达。ceRNA可以通过应答元件（microRNA response elements，MREs)与microRNA结合从而影响microRNA导致的基因沉默，这

ceRNA（competing endogenous RNAs，竞争性内源RNA）假说揭示了一种RNA间相互作用的新机制。已知microRNA可以通过结合mRNA导致基因沉默，而ceRNA可以通过竞争性地结合microRNA来调节基因表达。ceRNA可以通过应答元件（microRNA response elements，MREs)与microRNA结合从而影响microRNA导致的基因沉默，这揭示了一条RNA->microRNA调节通路的存在，具有重大生物意义ceRNA代表一种全新的基因表达调控模式，比起miRNA调控网络，ceRNA调控网络更为精细和复杂，涉及更多RNA分子，包括mRNA、假基因、长链非编码RNA和miRNA等。2011年，Pandolfi等人在“A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?”这篇文章中，Pandolfi等人提出了一种关于信使RNAs如何转录假基因，以及长链非编码RNAs如何相互“交流”的新假说，这些进一步的研究将有助于癌症等疾病的分子机理的解析

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2017-07-20 cbl0002_31992095

很有用，谢谢

90 0
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2016-08-28 般若傻瓜

#eRNA#

53 0
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2016-03-23 yangjxjc

#竞争性内源RNA#

73 0
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2015-12-27 hixiaoluo

好文章，值得收藏

148 0
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2015-12-05 gjsgj

#ceRNA#

53 0
[GetPortalCommentsPageByObjectIdResponse(id=224219, encodeId=00fa22421926, content=很有用，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ba52093518, createdName=cbl0002_31992095, createdTime=Thu Jul 20 10:49:29 CST 2017, time=2017-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008717, encodeId=a7e02008e1792, content=<a href='/topic/show?id=db6969548d' target=_blank style='color:#2F92EE;'>#eRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6954, encryptionId=db6969548d, topicName=eRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Sun Aug 28 11:00:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999115, encodeId=ea5419991153f, content=<a href='/topic/show?id=8c65e564367' target=_blank style='color:#2F92EE;'>#竞争性内源RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75643, encryptionId=8c65e564367, topicName=竞争性内源RNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Wed Mar 23 11:00:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49074, encodeId=d70f490e47c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 09:01:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521807, encodeId=7929152180e1e, content=<a href='/topic/show?id=7b9445054f' target=_blank style='color:#2F92EE;'>#ceRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4505, encryptionId=7b9445054f, topicName=ceRNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e16111401001, createdName=gjsgj, createdTime=Sat Dec 05 07:00:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44665, encodeId=4f25446651c, content=不好研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=974f1667182, createdName=杨晨舟, createdTime=Thu Dec 03 23:52:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44580, encodeId=309544580eb, content=收藏先, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Dec 03 18:25:00 CST 2015, time=2015-12-03, status=1, ipAttribution=)]
2015-12-03 杨晨舟

不好研究

142 0
[GetPortalCommentsPageByObjectIdResponse(id=224219, encodeId=00fa22421926, content=很有用，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ba52093518, createdName=cbl0002_31992095, createdTime=Thu Jul 20 10:49:29 CST 2017, time=2017-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008717, encodeId=a7e02008e1792, content=<a href='/topic/show?id=db6969548d' target=_blank style='color:#2F92EE;'>#eRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6954, encryptionId=db6969548d, topicName=eRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Sun Aug 28 11:00:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999115, encodeId=ea5419991153f, content=<a href='/topic/show?id=8c65e564367' target=_blank style='color:#2F92EE;'>#竞争性内源RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75643, encryptionId=8c65e564367, topicName=竞争性内源RNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Wed Mar 23 11:00:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49074, encodeId=d70f490e47c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 09:01:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521807, encodeId=7929152180e1e, content=<a href='/topic/show?id=7b9445054f' target=_blank style='color:#2F92EE;'>#ceRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4505, encryptionId=7b9445054f, topicName=ceRNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e16111401001, createdName=gjsgj, createdTime=Sat Dec 05 07:00:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44665, encodeId=4f25446651c, content=不好研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=974f1667182, createdName=杨晨舟, createdTime=Thu Dec 03 23:52:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44580, encodeId=309544580eb, content=收藏先, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Dec 03 18:25:00 CST 2015, time=2015-12-03, status=1, ipAttribution=)]
2015-12-03 lovetcm

收藏先

129 0

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