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Neurology:立体定向放射外科(SRS)治疗难治性三叉神经痛,越早越好!

2015-12-28 MedSci MedSci原创

该研究的目的是评估立体定向放射外科(SRS)被作为治疗难治性三叉神经痛的第一次手术后更好的结果的相关因素。总共有121名(平均年龄72岁)药物难治性疼痛患者,没有事先接受伽玛刀SRS作为初始治疗三叉神经痛的手段。使用一个4毫米等中心点,患者接受的平均最大剂量为80Gy,送到由术中MRI确定的三叉神经的目标。中位随访时间为36个月。在中位时间1个月的时候,107(88%)例患者的疼痛得到了缓解(巴罗

该研究的目的是评估立体定向放射外科(SRS)被作为治疗难治性三叉神经痛的第一次手术后更好的结果的相关因素。

总共有121名(平均年龄72岁)药物难治性疼痛患者,没有事先接受伽玛刀SRS作为初始治疗三叉神经痛的手段。使用一个4毫米等中心点,患者接受的平均最大剂量为80Gy,送到由术中MRI确定的三叉神经的目标。中位随访时间为36个月。

在中位时间1个月的时候,107(88%)例患者的疼痛得到了缓解(巴罗神经学研究所[BNI]得分I-IIIA)。早些时候接受SRS的患者(疼痛发作3年以内)直至疼痛缓解有一个较短的时间间隔(1周,P<0.001),药物缓解疼痛需要一个较长的时间间隔(BNI-I,P<0.001),并有充分的疼痛控制持续时间较长(BNI-I-IIIa,p<0.001)。在三叉神经痛诊断后1,2,3,和超过3年的患者接受SRS中位无疼痛的间隔分别为68,37,36,和10个月。接受SRS前3周之内对SRS有反应的患者,与那些反应时间较长的患者相比,SRS疼痛完全缓解持续时间较长(P=0.001)。15例(12%)患者SRS后报告有新的感觉异常。

作为初始外科手术治疗难治性三叉神经痛,早期的SRS管理比晚期使用SRS更快,更好,能够更长时间的缓解疼痛。

原始出处:

Seyed H. Mousavi,Ajay Niranjan,Marshall J. Huang,et al.Early radiosurgery provides superior pain relief for trigeminal neuralgia patients,Neurology,2015.12.22

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    2016-10-22 nian.wang1982
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    2016-11-16 liao1632
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    2016-09-15 yinhl1978
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    2015-12-30 freve
  8. [GetPortalCommentsPageByObjectIdResponse(id=1986478, encodeId=469b19864e8d4, content=<a href='/topic/show?id=160be5596d3' target=_blank style='color:#2F92EE;'>#立体定向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75596, encryptionId=160be5596d3, topicName=立体定向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Sun Jul 24 19:34:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967967, encodeId=04c4196e967ed, content=<a href='/topic/show?id=51c91669428' target=_blank style='color:#2F92EE;'>#SRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16694, encryptionId=51c91669428, topicName=SRS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f63175, createdName=nian.wang1982, createdTime=Sat Oct 22 13:34:00 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1768993, encodeId=f2da1e68993f3, content=<a href='/topic/show?id=d7674593e05' target=_blank style='color:#2F92EE;'>#定向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45937, encryptionId=d7674593e05, topicName=定向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920637977772, createdName=liao1632, createdTime=Wed Nov 16 15:34:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739250, encodeId=32381e3925039, content=<a href='/topic/show?id=6a9f1959e07' target=_blank style='color:#2F92EE;'>#三叉神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19597, encryptionId=6a9f1959e07, topicName=三叉神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19e234497376, createdName=小华子, createdTime=Mon May 16 20:34:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999625, encodeId=aeef19996259e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Sep 15 16:34:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1410745, encodeId=e7391410e4554, content=<a href='/topic/show?id=7dad19600f8' target=_blank style='color:#2F92EE;'>#三叉神经痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19600, encryptionId=7dad19600f8, topicName=三叉神经痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f67c2785166, createdName=yangeasy, createdTime=Wed Dec 30 03:34:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528303, encodeId=477c1528303ee, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Wed Dec 30 03:34:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540806, encodeId=40ac1540806a8, content=<a href='/topic/show?id=ac8de440615' target=_blank style='color:#2F92EE;'>#神经痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74406, encryptionId=ac8de440615, topicName=神经痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d8213287489, createdName=贵阳, createdTime=Wed Dec 30 03:34:00 CST 2015, time=2015-12-30, status=1, ipAttribution=)]
    2015-12-30 贵阳
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