Arthritis Rheumatol：Tocilizumab可有效治疗JIA相关葡萄膜炎

2016-10-11 Mechront 译 MedSci原创

近期有研究称，对于重症幼年特发性关节炎相关的葡萄膜炎、既往常规免疫抑制药物和至少一种抗肿瘤坏死因子剂治疗失败的患者，Tocilizumab治疗是有效的。研究人员进行了一项多中心研究，纳入了25例重症幼年特发性关节炎相关的葡萄膜炎、既往常规免疫抑制药物和至少一种抗肿瘤坏死因子剂治疗失败的患者，治疗药物包括阿达木单抗（n = 24）、依那西普（n =8）、英夫利昔单抗（n =7）、阿巴西普（n

近期有研究称，对于重症幼年特发性关节炎相关的葡萄膜炎、既往常规免疫抑制药物和至少一种抗肿瘤坏死因子剂治疗失败的患者，Tocilizumab治疗是有效的。

研究人员进行了一项多中心研究，纳入了25例重症幼年特发性关节炎相关的葡萄膜炎、既往常规免疫抑制药物和至少一种抗肿瘤坏死因子剂治疗失败的患者，治疗药物包括阿达木单抗（n = 24）、依那西普（n =8）、英夫利昔单抗（n =7）、阿巴西普（n =6）、利妥昔单抗（n = 2）、阿那白滞素（n = 1）和戈利木单抗（n = 1）。

这些患者中，21为女性，平均年龄为18.5岁。起病时，22例患者有双侧性眼炎。此外，13例患者有白内障；12例带状角膜病变；10例粘连；九例黄斑囊样水肿（CME）；7例青光眼和5例弱视。

所有患者接受8 mg tocilizumab (Actemra, Genentech)，每4周一次，共6个月，中位随访时间为12个月。

治疗后，79.2%的患者其前室细胞数得到改善；第1年时该数据达到88.2%。CME患者的黄斑中心凹厚度从401.7 µm减少到259.1 µm。随访过程中，19例葡萄膜炎达到完全缓解。

显著的不良事件是严重的自身免疫性血小板减少症、肺炎、自身免疫性贫血和血小板减少、病毒性结膜炎和大疱性脓疱病。

研究结果表明，对于这一类患者，tocilizumab是有效的治疗药物。

原始出处：

Calvo-Rio V, et al. Anti-IL6-R Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis Refractory to anti-TNF therapy. A multicenter study of 25 patients.Arthritis Rheumatol. 2016;doi:10.1002/art.39940.

Second-line tocilizumab seen as effective in patients with JIA-associated uveitis.Healio.October 10, 2016

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2017-04-30 snf701207

#mAb#

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2017-08-23 ms6390871039024434

#Arthritis#

98 0
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2016-10-27 Liufeng6206

学习！不错！

168 0
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2016-10-16 七九九八

写的好，分享了

133 0
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2016-10-15 七九九八

写的不错，分享

134 0
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2016-10-14 七九九八

好东西，分享了

144 0
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2016-10-13 七九九八

赞一个

173 0
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2016-10-13 zhaojie88

#ART#

47 0
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style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Oct 13 08:00:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454997, encodeId=7cb3145499e8d, content=<a href='/topic/show?id=923a10296b9' target=_blank style='color:#2F92EE;'>#JIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10296, encryptionId=923a10296b9, topicName=JIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c48e5623632, createdName=lujian, createdTime=Thu Oct 13 08:00:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619447, encodeId=3768161944e7f, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Oct 13 08:00:00 CST 2016, time=2016-10-13, status=1, ipAttribution=)]
2016-10-13 lujian

#JIA#

117 0
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GetPortalCommentsPageByObjectIdResponse(id=1619447, encodeId=3768161944e7f, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Oct 13 08:00:00 CST 2016, time=2016-10-13, status=1, ipAttribution=)]
2016-10-13 docwu2019

#有效治疗#

66 0

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