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Sci Rep：卵巢癌对顺铂耐药的新机制

2017-05-08 MedSci MedSci原创

卵巢癌顺铂耐药
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高级别浆液性卵巢癌是最常见的卵巢癌。虽然手术和铂类-紫杉烷化疗的组合提供了有效的治疗，但耐药性常常发生，导致不良结果。近期，一项发表在杂志Sci Rep上的研究旨在阐明其耐药性的分子机制。研究者们从患者的恶性腹水细胞中检查了与高级别浆液性卵巢癌耐药性发展相关的DNA甲基化和转录组学变化。与大规模转录组变化相一致，顺铂耐药与位于基因组基因间区域的几个CpG位点的超甲基化丧失相关。转录组和CpG甲基化

高级别浆液性卵巢癌是最常见的卵巢癌。虽然手术和铂类-紫杉烷化疗的组合提供了有效的治疗，但耐药性常常发生，导致不良结果。


近期，一项发表在杂志Sci Rep上的研究旨在阐明其耐药性的分子机制。

研究者们从患者的恶性腹水细胞中检查了与高级别浆液性卵巢癌耐药性发展相关的DNA甲基化和转录组学变化。

与大规模转录组变化相一致，顺铂耐药与位于基因组基因间区域的几个CpG位点的超甲基化丧失相关。

转录组和CpG甲基化对响应顺铂治疗的敏感性和细胞耐药的变化很小，这表明，翻译后机制在调节细胞死亡或存活的重要性。

耐药细胞对高浓度顺铂的反应揭示了耐药性潜在关键驱动因素，如KLF4的转录组学变化。其中最强烈的变化也诱导了耐药细胞中的IL6的表达，并且其表达在对顺铂的反应中进一步增加。

此外，IL6信号传导的其他几个成分也受到影响，这也进一步支持了其对恶性转化和卵巢癌耐药性发展的重要性。

原始出处：
Lund RJ1, Huhtinen K , et al. DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer. Sci Rep. 2017 May 4;7(1):1469. doi: 10.1038/s41598-017-01624-4. 

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    2017-08-10 ms3153534357578991

    #铂#

    0

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    2017-09-01 yeye5224612

    #顺铂耐药#

    0

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    2017-05-10 龙胆草

    学习了，谢谢分享

    0

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    2017-05-09 龙胆草

    学习了，谢谢分享

    0

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