Phytother Res：百里醌对睾丸素诱导的良性前列腺增生具有抑制作用

2017-10-04 AlexYang MedSci原创

最近，有研究人员阐释了在大鼠中，百里醌（TQ）对试验条件下诱导的良性前列腺增生（BPH）的发展具有可能的保护性作用。在试验中，18只成年雄性大鼠分为3个小组；阴性对照组（n=6）接受介质注射，另外两个组接受皮下睾丸素注射（3mg/kg）。再将接受睾丸素注射的大鼠随机分成BPH不处理组（n=6）和BPH+TQ处理组（n=6，5mg/kg口服14天）。研究人员还分析了组织学变化和转变生长因子-β1（T

最近，有研究人员阐释了在大鼠中，百里醌（TQ）对试验条件下诱导的良性前列腺增生（BPH）的发展具有可能的保护性作用。在试验中，18只成年雄性大鼠分为3个小组；阴性对照组（n=6）接受介质注射，另外两个组接受皮下睾丸素注射（3mg/kg）。再将接受睾丸素注射的大鼠随机分成BPH不处理组（n=6）和BPH+TQ处理组（n=6，5mg/kg口服14天）。研究人员还分析了组织学变化和转变生长因子-β1（TGF-β1）以及血管内皮生长因子A（VEGF-A）的mRNA水平。另外，研究人员还定量了二氢睾酮和白介素-6（IL-6）血清水平。研究表明，在BPH大鼠未处理组，前列腺重/体重比值、前列腺表皮厚度、血清IL-6和二氢睾酮水平、TGF-β1和VEGF-A的前列腺表达水平均显著增加。在BPH大鼠中的前列腺组织检查表明了基质区域和腺上皮增殖水平提高，并且具有丰富的管腔内的乳头状褶皱。然而，研究人员在BPH+TQ处理大鼠中与未处理BPH大鼠比较，观察到了前列腺重/体重比值、前列腺表皮厚度、血清IL-6和二氢睾酮水平、TGF-β1和VEGF-A的前列腺表达水平的减少。最后，研究人员指出，这些结果支持了T

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2017-10-14 124987a0m73(暂无昵称)

#抑制作用#

69 0
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2017-10-11 麦解佬

学习

449 0
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2017-10-06 zhangph

#睾丸#

67 0
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2017-10-06 weihongyv

#睾丸素#

52 0
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2017-10-06 刘阔

#良性前列腺增生#

84 0
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2017-10-04 清风拂面

谢谢分享.学习了

70 0
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2017-10-04 1ddf0692m34(暂无匿称)

学习了.涨知识

69 0
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2017-10-04 中医痴

不错的.学习了.谢谢分享!

68 0

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