Cell Rep：疟疾是这样发生的

2015-12-30 佚名生物谷

澳大利亚科学家近日研究揭示了疟原虫如何引发机体的炎性反应，相关研究刊登在国际杂志Cell Reports上，文章中研究者揭示了疟原虫如何破坏机体抵御疾病的能力，为后期科学家们通过增强机体关键的免疫力来开发新型疟疾疫苗提供了新的思路。

澳大利亚科学家近日研究揭示了疟原虫如何引发机体的炎性反应，相关研究刊登在国际杂志Cell Reports上，文章中研究者揭示了疟原虫如何破坏机体抵御疾病的能力，为后期科学家们通过增强机体关键的免疫力来开发新型疟疾疫苗提供了新的思路。

来自沃尔特与伊丽莎-霍尔研究所(Walter and Eliza Hall Institute)的科学家们发现，在临床和严重性疟疾中驱动机体免疫反应的相同炎性分子也会抑制机体产生保护性的抗体来抵御疟疾发生，文章中研究人员首次报道了为何机体免疫系统不会在疟疾感染期间产生免疫力。Hansen博士说道，在很多感染中，病原体的单一暴露都足以诱导机体产生抗体来在后期保护机体抵御相同的病原体，然而疟疾却是个特例，感染疟疾的患者仍然还会对疟疾更加易感，而且身体素质会越来越脆弱。

从传统角度来讲疟疾很难治疗，因为机体并不善于开发出长效的免疫力来抵御疟原虫的感染，实际上研究者并不清楚是否是疟原虫本身还是机体对疟原虫的炎性反应在抑制机体产生保护性的免疫力，如今研究者发现这其实是一把双刃剑，即参与并且驱动严重临床疟疾的强烈的炎性反应或许也是沉默机体关键免疫细胞保护机体抵御疟原虫感染的元凶，机体释放的抵御感染的炎性分子同时也可以抑制保护性抗体的产生，而针对疟疾和其它病原体的长效免疫力也需要抗体的反应。

机体的辅助T细胞可以驱动B细胞产生足够的保护性抗体，然而研究者却发现，在疟疾感染期间，关键的炎性分子实际上会阻断辅助T细胞的产生，从而使得B细胞不能够产生必要的抗体来抵御疟原虫的感染。最后研究者表示，本文研究对于后期开发有效的疟疾疫苗及开发治疗性的手段提供了新的思路。

截止到目前，疟疾疫苗的开发尚未成功，而本文研究或许提出了一种新型的思路，研究者将通过增强辅助T细胞的功能来刺激机体产生更多的抗体，最终开发出长效的疟疾疫苗。

原始出处：

Victoria Ryg-Cornejo, Lisa Julia Ioannidis,et al.Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation.Cell Reports.Dec 24,2015

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2016-10-21 维他命

#CEL#

52 0
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2016-02-07 zhaozhouchifen

#Cell#

57 0
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2016-01-08 andruhn

好东西，值得分享，学习了！

137 0
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2016-01-03 lu2996

支持

159 0
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2016-01-03 lu2996

很有用

122 0
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2015-12-31 冰沸点点

内容新

141 0
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2015-12-31 忠诚向上

很专业

207 0
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2015-12-31 忠诚向上

有内容

114 0
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2015-12-30 lu2996

国外研究还是比较好的

97 0
[GetPortalCommentsPageByObjectIdResponse(id=1959530, encodeId=537f1959530b6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Oct 21 17:06:00 CST 2016, time=2016-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869274, encodeId=d9e618692e4d2, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Feb 07 13:06:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54669, encodeId=bc215466950, content=好东西，值得分享，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69b61619007, createdName=andruhn, createdTime=Fri Jan 08 19:36:00 CST 2016, time=2016-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51352, encodeId=404251352f7, content=支持, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Sun Jan 03 04:00:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51351, encodeId=2d6f51351f7, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Sun Jan 03 03:59:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50802, encodeId=e32e5080200, content=内容新, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151231/IMG5684A3A3C92AE9089.jpg, createdBy=c5e91675709, createdName=冰沸点点, createdTime=Thu Dec 31 14:06:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50782, encodeId=a93250e8239, content=很专业, beContent=null, objectType=article, channel=null, level=null, likeNumber=207, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Dec 31 12:51:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50783, encodeId=78d350e8333, content=有内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Dec 31 12:51:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50509, encodeId=db3d5050931, content=国外研究还是比较好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Wed Dec 30 14:05:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50510, encodeId=367150510a4, content=对疾病研究详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1b91651063, createdName=lu2996, createdTime=Wed Dec 30 14:05:00 CST 2015, time=2015-12-30, status=1, ipAttribution=)]
2015-12-30 lu2996

对疾病研究详细

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