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Eur Heart J：端粒长度缩短率与心血管损伤相关

2014-06-26 高晓方 译 医学论坛网

端粒长度心血管损伤
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英国一项研究表明，中年后期白细胞端粒长度(LTL)缩短率与心血管损伤显著相关，并且独立于传统心血管危险因素。论文于6月22日在线发表于《欧洲心脏杂志》(Eur Heart J)。 此项研究从NSHD调查中纳入了在53和60～64岁时测定LTL和传统心血管危险因素，并且在60～64岁时测定颈动脉内中膜厚度(cIMT)、心脏质量和左室功能的受试者。LTL通过实时PCR加以测定。 结果显示，共有10

英国一项研究表明，中年后期白细胞端粒长度(LTL)缩短率与心血管损伤显著相关，并且独立于传统心血管危险因素。论文于6月22日在线发表于《欧洲心脏杂志》(Eur Heart J)。

此项研究从NSHD调查中纳入了在53和60～64岁时测定LTL和传统心血管危险因素，并且在60～64岁时测定颈动脉内中膜厚度(cIMT)、心脏质量和左室功能的受试者。LTL通过实时PCR加以测定。

结果显示，共有1033例受试者同时具备两个时间点的LTL数据。尽管53岁时LTL与60～64岁时心血管表型无相关性，但LTL与60～64岁时cIMT具有负相关性(P=0.015)。然而，53和60～64岁时端粒缩短率与60～64岁时cIMT值具有最显著相关性(P=0.006)。对传统心血管危险因素进行校正后上述相关性未受影响。心脏指标与横断面和纵向LTL测定无相关性。

原始出处：

Stefano Masi1,2,†, Francesco D'Aiuto3,†, Carmen Martin-Ruiz4, Tauseef Kahn1, Andrew Wong5, Arjun K. Ghosh5, Peter Whincup6, Diana Kuh5, Alan Hughes7, Thomas von Zglinicki4, Rebecca Hardy5, John Eric Deanfield1,8,*, on behalf of the NSHD scientific and data collection teams.Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort.Eur Heart J.June 22, 2014.doi: 10.1093/eurheartj/ehu226

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    2014-10-18 bbwuyu_013

    #血管损伤#

    0

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    2014-06-28 doctor-chen9582

    #端粒长度#

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    2014-06-28 zhaojie88

    #ART#

    0

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    2014-06-28 智者为医08

    #损伤#

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    2014-06-28 爆笑小医

    #HEART#

    0

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