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ATVB:青春期体重指数变化与成年男性冠状动脉粥样硬化和急性冠状动脉事件相关

2021-06-17 MedSci原创 MedSci原创

青春期BMI变化是成年男性CAC评分和急性冠脉事件风险的独立预测因子。青春期BMI过度增加可能引发冠状动脉粥样硬化,从而增加成人急性冠状动脉事件的风险和严重程度。

近日,血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,该研究旨在评估青春期体重指数(BMI)变化与成年期冠状动脉钙化(CAC)评分和急性冠脉事件风险之间的关系。

研究人员从BMI流行病学研究中纳入了37672名男性,并计算了他们的青春期BMI变化(20岁的BMI-8岁的BMI)。研究人员获得的首次急性冠状动脉事件信息来自瑞典国家登记中心(n=37672,n=1873)。

青春期BMI变化(每增加SD的比值比为1.32[1.14-1.52])与中年CAC评分≥1有关,但与儿童期BMI无关。在CAC分析和包含主要心血管危险因素在内的模型中对中年BMI进行调整后,青春期BMI变化与CAC之间的关联仍然存在。

生存曲线

与从未超重的男性相比,在青春期超重的个体(风险比为2.11[1.79-2.49]),但那些在青春期体重正常的8岁超重儿童则不然,急性冠状动脉事件的风险显著增加。在急性冠状动脉疾病患者中,青春期超重的个体因该事件死亡的风险增加。

由此可见,青春期BMI变化是成年男性CAC评分和急性冠脉事件风险的独立预测因子。青春期BMI过度增加可能引发冠状动脉粥样硬化,从而增加成人急性冠状动脉事件的风险和严重程度

原始出处:

Jenny M. Kindblom.et al.Pubertal Body Mass Index Change Is Associated With Adult Coronary Atherosclerosis and Acute Coronary Events in Men.ATVB.2021.https://www.ahajournals.org/doi/10.1161/ATVBAHA.121.316265

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    2021-06-18 gongliu
  2. [GetPortalCommentsPageByObjectIdResponse(id=1977995, encodeId=9e3819e79952b, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Fri Jun 18 19:32:31 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944708, encodeId=57691944e08e2, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Thu Jan 06 15:32:31 CST 2022, time=2022-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977444, encodeId=11ad9e74447b, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ef41805476, createdName=ms4630379895335417, createdTime=Sun Jun 27 23:17:31 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975263, encodeId=fe1e9e52630d, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Sun Jun 20 22:44:46 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275561, encodeId=1d9712e556172, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Sat Jun 19 13:32:31 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974567, encodeId=e2199e456799, content=锻炼身体很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Fri Jun 18 07:37:08 CST 2021, time=2021-06-18, status=1, ipAttribution=)]
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    2021-06-27 ms4630379895335417

    认真学习

    0

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    2021-06-20 smart Ren

    认真学习

    0

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    2021-06-18 学医无涯

    锻炼身体很重要

    0

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最新研究发现,大约每340人中就有1人可能携带MC4R的单基因突变。携带这些基因突变的人从幼儿期起,就拥有更大的体重,到18岁时,他们的平均体重高出约17公斤,其中过量的体重大部分是脂肪。

近200万人的大型研究分析:多喝牛奶会增加心脏代谢风险吗?

牛奶富含蛋白质、钙、脂肪和多种微量元素,是我们膳食中重要的营养来源。

《柳叶刀》子刊:预测非白人糖尿病的BMI阈值应降低,WHO现行建议有风险!

BMI是对个人超重程度进行分类的确定方法。近30年前的1993年,WHO的一个专家委员会提议,1级超重的BMI界值点为25•0–29•9 kg/m2

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