JCEM：hCG+甲状腺功能，能否预测子痫前期风险？

2016-09-26 Moon 译 MedSci原创

在怀孕期间，对甲状腺激素的需求有所增加。妊娠时产生的人绒毛膜促性腺激素（HCG）是甲状腺功能的重要生理刺激。已有研究表明，母亲T4浓度位于正常高限时，子痫前期风险也会变高。我们研究的假设为：根据HCG浓度可以区分高甲状腺功能的生理形式、高甲状腺功能的病理形式，以及这两种不同形式下的子痫前期风险也会是不同的。这项以人群为基础的前瞻性队列研究，检测了5146名孕妇的TSH、FT4、hC

在怀孕期间，对甲状腺激素的需求有所增加。妊娠时产生的人绒毛膜促性腺激素（HCG）是甲状腺功能的重要生理刺激。已有研究表明，母亲T4浓度位于正常高限时，子痫前期风险也会变高。

我们研究的假设为：根据HCG浓度可以区分高甲状腺功能的生理形式、高甲状腺功能的病理形式，以及这两种不同形式下的子痫前期风险也会是不同的。

这项以人群为基础的前瞻性队列研究，检测了5146名孕妇的TSH、FT4、hCG或TPO-抗体水平。

结果显示，高hCG+高甲状腺功能孕妇，与正常甲状腺功能的孕妇相比，子痫前期风险并没有变得更高；但是低hCG+高甲状腺功能孕妇，与正常甲状腺功能的孕妇相比，子痫前期风险高出3.4-11.1倍。这些风险估计在高BMI女性中被放大。低HCG+TSH抑制(<0.10 mU/L)的孕妇，子痫前期风险高出3.2-8.9倍。hCG与子痫前期无关；TPO抗体阳性的女性排除后，结果仍然相同。

这项研究表明，与高hCG+高甲状腺功能孕妇相比，低hCG+高甲状腺功能孕妇有更高的子痫前期风险。因此，检测hCG可以帮助区分当下的稿甲状腺功能是生理上的还是病理上的，根据不同hCG浓度，还能判断孕妇子痫前期风险。

原始出处：

Korevaar TI.et al.The risk of pre-eclampsia according to high thyroid function in pregnancy differs by hCG concentration.J Clin Endocrinol Metab. 2016 Sep 20:jc20162397. [Epub ahead of print]

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2016-11-22 achengzhao

#JCE#

60 0
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2017-04-19 smallant2015

#JCEM#

54 0
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2016-10-11 1e0d99ddm02(暂无匿称)

总结的很好！

124 0
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content=谢谢分享，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 14:48:52 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-10-11 1e0d99ddm02(暂无匿称)

分享一下！

1 0
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2016-10-01 doctorJiangchao

继续关注

126 0
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2016-10-01 doctorJiangchao

继续学习

147 0
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content=谢谢分享，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 14:48:52 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-09-28 yahu

#子痫前期#

53 0
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beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8552, encryptionId=04f98552df, topicName=hCG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec053077747, createdName=zgwhgch, createdTime=Wed Sep 28 11:18:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136024, encodeId=72b113602408, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 14:49:01 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136023, encodeId=83ac13602356, content=谢谢分享，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 14:48:52 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-09-28 zgwhgch

#hCG#

99 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Oct 01 15:05:43 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366547, encodeId=4f98136654ead, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed Sep 28 11:18:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414656, encodeId=92b1141465654, content=<a href='/topic/show?id=04f98552df' target=_blank style='color:#2F92EE;'>#hCG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8552, encryptionId=04f98552df, topicName=hCG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec053077747, createdName=zgwhgch, createdTime=Wed Sep 28 11:18:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136024, encodeId=72b113602408, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 14:49:01 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136023, encodeId=83ac13602356, content=谢谢分享，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 14:48:52 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-09-27 医路开来

很不错的文章

100 0
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beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8552, encryptionId=04f98552df, topicName=hCG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec053077747, createdName=zgwhgch, createdTime=Wed Sep 28 11:18:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136024, encodeId=72b113602408, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 14:49:01 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136023, encodeId=83ac13602356, content=谢谢分享，，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 14:48:52 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
2016-09-27 医路开来

谢谢分享，，，

47 0

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JCEM：hCG+甲状腺功能，能否预测子痫前期风险？

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JCEM：hCG+甲状腺功能，能否预测子痫前期风险？

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