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Diabetes Care:晚发T1DM和较大年龄可预测其它自身免疫性疾病的风险

2018-10-26 xing.T MedSci原创

由此可见,T1DM患者的AID患病率随着年龄的增长和女性而增加。T1DM的晚期发病是发生其它AID的独立且重要的危险因素。在老年人中被诊断患有T1DM的个体,特别是女性,应该监测其它自身免疫疾病。

1型糖尿病(T1DM)与其他自身免疫性疾病(AID)有关,这些AID可能对健康造成严重后果。T1DM患者中AID的流行病学尚未明确。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,在这项横断面队列研究中,研究人员试图描述各年龄段T1DM成人AID的发病年龄和患病率。

研究人员纳入在2011年至2018年期间到华盛顿大学糖尿病中心就诊的1212名成年人,并收集了患者的年龄、性别、种族和发病数据。研究人员基于T1DM的年龄开始进行配对关联分析。多变量Logistic回归用于评估性别、种族、T1DM发病年龄和T1DM持续时间对其它AID患病率的独立影响。

T1DM发病的平均年龄为21.2±14.4岁。AID发病率和患病率随年龄增长而增加。女性可强烈预测AID风险。最常见的T1DM相关AID是甲状腺疾病、胶原血管疾病和恶性贫血。T1DM发病年龄和T1DM持续时间可预测AID风险。30岁以后的晚发性T1DM患者发生其它AID的风险高于T1DM发病年龄较小的患者。

由此可见,T1DM患者的AID患病率随着年龄的增长和女性而增加。T1DM的晚期发病是发生其它AID的独立且重要的危险因素。在老年人中被诊断患有T1DM的个体,特别是女性,应该监测其它自身免疫疾病。

原始出处:

Jing W. Hughes,et al.Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease.Diabetes Care.2018.https://doi.org/10.2337/dc18-1157

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