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Hypertension:65岁及以上男性收缩压与血管疾病有啥关系!

2017-04-25 xing.T MedSci原创

即使在85-94岁的患者中,仍然有证据表明SBP和主要血管事件之间存在正相关性:常规SBP每升高10mmHg与主要血管事件的风险增加14%相关(95%可信区间1%-30%)。

血压与老年血管疾病之间的相关性存在不确定性。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员在一项有7564名参与者的前瞻性队列研究评估了收缩压(SBP)与主要血管事件之间的相关性。

该研究的这些参与者年龄在65-94岁,并且在1996-1999年期间从西澳大利亚珀斯的一般人群中进行招募的。研究人员在研究之初和2001-2004年期间重新调查时分别测量了SBP。研究人员对参与者的致命和非致命的血管事件进行了监测。为了限制反向因果关系的影响,分析被限制在基线之前没有血管疾病的男性中进行。研究人员采用Cox回归估计风险比,调整了年龄和受教育程度(进一步调整并没有实质性地改变这种相关性)。

在平均随访11年期间,共有1557次主要的血管事件。研究人员发现在整个SBP检查范围(145-170mmHg)内,常规SBP和主要血管事件风险之间存在连续对数线性相关性。总体而言,常规SBP每升高10mmHg与主要血管事件的风险增加20%相关(风险比为19%;95%可信区间为13%-26%;发生事件的平均年龄为80岁)。有证据表明缺血性心脏病和卒中与受年龄影响的效应呈正相关,但与年龄较大相关性较小。

即使在85-94岁的患者中,仍然有证据表明SBP和主要血管事件之间存在正相关性:常规SBP每升高10mmHg与主要血管事件的风险增加14%相关(95%可信区间1%-30%)。

原始出处:

Ben Lacey, et al. Systolic Blood Pressure and Vascular Disease in Men Aged 65 Years and Over The HIMS (Health in Men Study).Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.117.09150

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