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Am J Psychiat：脑部炎症与精神分裂症之间的风险关系

2015-10-23 zhaoshuang 译 MedSci原创

脑部炎症精神分裂症
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一项新的研究表明，在精神分裂症患者和那些具有精神分裂高风险的患者大脑内，免疫细胞（(小胶质细胞)更活跃，表明神经炎性反应是精神分裂的一个重要因素，并成为了治疗和预防精神分裂症的一个新的潜在目标。

研究者使用正电子发射断层扫描测量56个成年人的小胶质活动，其中14人被诊断患有精神分裂症，14人有精神病“超高风险”，28个健康人作为对照。他们发现，与对照组相比，“超高风险”精神病患者的小胶质细胞在灰质中活动性增强(Cohen's d > 1.2)，并与症状的严重程度呈正相关(r = 0.730)，精神分裂症患者的小胶质活动性也增强(Cohen's d >1.7)。

精神分裂症同其他精神疾病一样，是一种由于基因、行为以及其他一些因素相互作用所导致的复杂疾病。

这项研究将会激发其他的一些研究，比如大脑炎症与阿尔茨海默氏症、精神分裂症和抑郁症等疾病之间的相关性，而这些新的研究将会进一步改进精神分裂症的治疗。

研究者提出抗炎治疗可能有效预防精神病的发作；从精神病理学角度来看，抗炎药物辅助治疗精神分裂症可适度提高疗效。

原始出处：

Megan Brooks.Brain Inflammation Linked to Schizophrenia Risk.Medscape Medical News . October 21, 2015

Bloomfield PS, Selvaraj S,et al.Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study.Am J Psychiatry. 2015 Oct 16

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1404013, encodeId=4be21404013cb, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIXE1PadWxBeosSHpB06cC9uZflHWBnMib5rSPbq29kzxyzUPEqWfvlNl0DMmX9070Gdwbq4zwg4vg/132, createdBy=bfe92444551, createdName=bnurmamat, createdTime=Sun Oct 25 00:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40458, encodeId=18c44045895, content=这是显而易见的, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Oct 23 14:20:00 CST 2015, time=2015-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40420, encodeId=62ee4042075, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150925/IMG560509F273F627198.jpg, createdBy=6dc51652582, createdName=chucklehead, createdTime=Fri Oct 23 12:53:00 CST 2015, time=2015-10-23, status=1, ipAttribution=)]
    2015-10-25 bnurmamat

    #精神分裂#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1404013, encodeId=4be21404013cb, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIXE1PadWxBeosSHpB06cC9uZflHWBnMib5rSPbq29kzxyzUPEqWfvlNl0DMmX9070Gdwbq4zwg4vg/132, createdBy=bfe92444551, createdName=bnurmamat, createdTime=Sun Oct 25 00:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40458, encodeId=18c44045895, content=这是显而易见的, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Oct 23 14:20:00 CST 2015, time=2015-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40420, encodeId=62ee4042075, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150925/IMG560509F273F627198.jpg, createdBy=6dc51652582, createdName=chucklehead, createdTime=Fri Oct 23 12:53:00 CST 2015, time=2015-10-23, status=1, ipAttribution=)]
    2015-10-23 lixh1719

    这是显而易见的

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1404013, encodeId=4be21404013cb, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIXE1PadWxBeosSHpB06cC9uZflHWBnMib5rSPbq29kzxyzUPEqWfvlNl0DMmX9070Gdwbq4zwg4vg/132, createdBy=bfe92444551, createdName=bnurmamat, createdTime=Sun Oct 25 00:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40458, encodeId=18c44045895, content=这是显而易见的, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Oct 23 14:20:00 CST 2015, time=2015-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40420, encodeId=62ee4042075, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150925/IMG560509F273F627198.jpg, createdBy=6dc51652582, createdName=chucklehead, createdTime=Fri Oct 23 12:53:00 CST 2015, time=2015-10-23, status=1, ipAttribution=)]
    2015-10-23 chucklehead

    继续学习

    0

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