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啥?冬眠有望助力癌症治疗!

2017-02-22 佚名 生物探索

我们知道,蛇、蝙蝠、刺猬等动物会采取冬眠以度过寒冷的冬季,这一机制有助于它们应对天气恶劣以及食物紧缺等环境。那么,你相信人也能冬眠吗?近期,来自于意大利的科学家提出一个拯救晚期癌症患者生命的方法:使患者进入冬眠状态,并在此期间利用放射治疗,最终消灭癌症!


图为18岁癌症患者Patrick McGill (图片来源于:Getty Images)

对于晚期癌症患者,最大的难题并不是医生没有办法消灭癌症,而是病人本身的身体状况无法承受高剂量的辐射治疗。对于大多数癌症患者而言,癌转移是他们死亡的主要原因。这种状况下,传统的手术、放化疗已经无法完全清除转移多处的肿瘤。

为了“绝境重生”,来自于意大利国家核物理研究所的著名物理学家Marco Durante提出了一个解决方法:让患者冬眠,此期间利用高剂量放射治疗消灭肿瘤!BBC、Tech Times等外媒对这一“奇思妙想”进行了相关报道。

人冬眠?

进入冬季,很多动物(蛇、蝙蝠、刺猬……)会进入冬眠。通常,选择冬眠是动物为应对不利环境而做出的保护性行动,特别是当环境温度降低以及食物缺乏时。不同的动物,冬眠的时间、原因以及睡眠的深浅都不尽相同,且较为复杂。

对于人类而言,冬眠似乎并无必要。我们通常会借助其他渠道适应恶劣的环境。但是已有的对灵长类动物的研究表明,人类同样也有冬眠的潜能。那么,人是否能够安然冬眠呢?

某种程度上,当所处环境温度大幅度下降,人体的各项技能包括新陈代谢速率都会降低,以确保能够存活下来。瑞典一名放射科医生Anna Bagenholm曾意外跌入冰洞中超1个小时,导致体温下降至至13.7℃。这一事故虽然导致轻微的神经损伤,但是之后都完全康复了。

一个13个月大的婴儿(仅仅只穿着尿布)曾被遗弃在零下环境中。当她被发现时已经没有了心跳,但是当宝宝被放置在温暖的毛毯后,生命体征又恢复正常,且身体无严重损伤。医生们认为,她可能进入了一个类似冬眠的状态。

冬眠助力癌症治疗!

上述两个例子都展现了人冬眠的可行性。科学家们认为,身体进入深度睡眠状态,新陈代谢、心跳、呼吸速率、耗氧量等身体机能都慢下来,蛋白合成、基因表达等分子活动也会减弱。这种状态有助于提高机体修复DNA损伤的能力。

Durante相信,冬眠有望为晚期癌症患者带来新希望。他认为,晚期癌症患者进入冬眠状态,有望阻止癌细胞生长和扩散,从而为医生赢得更多的治疗时间和机会。理想情况是,当患者苏醒时,他们已经痊愈了。

科学家们发现,当身体进入静止状态,会主动避免化疗的毒副作用,甚至于抑制肿瘤的生长。在这种情况下,医生可以采用高剂量的辐射消灭癌细胞,且能够确保不伤害患者本身。

研究团队已经成功在小鼠身上进行了相关试验。下一步,他们将启动临床试验,计划让患者进入深度睡眠,并维持1周时间,以便让医生有足够的时间采用放射治疗。

他们希望,这一突破常理的方法有望在未来10年内实现拯救癌症患者生命的初衷。

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    2017-02-22 阿黎黎

    有点道理

    0

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    2017-02-22 明月清辉

    这样的方法很有心意

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1844203, encodeId=3c56184420304, content=<a href='/topic/show?id=06a2e1405a8' target=_blank style='color:#2F92EE;'>#癌症治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71405, encryptionId=06a2e1405a8, topicName=癌症治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbf451, createdName=陈吴1234, createdTime=Tue Jan 30 06:24:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739904, encodeId=23561e3990430, content=<a href='/topic/show?id=0e60310344e' target=_blank style='color:#2F92EE;'>#冬眠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31034, encryptionId=0e60310344e, topicName=冬眠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7e934597814, createdName=12498a49m71暂无昵称, createdTime=Tue Sep 26 07:24:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177474, encodeId=0c5f1e7474c1, content=有点道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NepTGY3QJjTpdCuPV3VVXfteDUXG7l0Ctg45QUWEgCtv9H8CZfofI2N7N9xbmw7ps42JxrmLSNMQibldtCHwolXQ/0, createdBy=ebf71943594, createdName=阿黎黎, createdTime=Wed Feb 22 18:55:20 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177425, encodeId=bac41e742581, content=这样的方法很有心意, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Feb 22 10:49:58 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177418, encodeId=92871e7418cf, content=长见识, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0512024297, createdName=赵泽斌, createdTime=Wed Feb 22 10:21:26 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177414, encodeId=c8121e7414dc, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Wed Feb 22 09:59:19 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177413, encodeId=b1c81e741366, content=具体怎么办?只有实践才可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=75651918956, createdName=WEIXIN84cfb6fd, createdTime=Wed Feb 22 09:58:43 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177412, encodeId=02521e741284, content=感觉还行!, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Wed Feb 22 09:55:17 CST 2017, time=2017-02-22, status=1, ipAttribution=)]
    2017-02-22 赵泽斌

    长见识

    0

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    2017-02-22 1771ae4158m

    学习一下很不错

    0

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    2017-02-22 WEIXIN84cfb6fd

    具体怎么办?只有实践才可以

    0

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    2017-02-22 明天会更好!

    感觉还行!

    0

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