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偏头痛往往伴有其他疾病,能不能断根

2017-05-09 李焰生/上海交通大学医学院附属仁济医院神经内科主任医师 澎湃新闻

最近,女大学生小张就来咨询,“近来开始经常头痛,发作时伴有恶心呕吐,严重时会卧床不起,影响了我的课业。我上网查了,觉得自己可能是得了偏头痛,我妈妈也有这头痛毛病。偏头痛能不能断根?我应该怎么办?”


最近,女大学生小张就来咨询,“近来开始经常头痛,发作时伴有恶心呕吐,严重时会卧床不起,影响了我的课业。我上网查了,觉得自己可能是得了偏头痛,我妈妈也有这头痛毛病。偏头痛能不能断根?我应该怎么办?”

根据小张描述的症状初步判断,可能是“偏头痛”。偏头痛是由遗传(约占60%)和其他还不明确的原因所导致的,发病机制是神经细胞的兴奋性不稳定,导致在一些内外环境因素变化(如月经周期、睡眠紊乱、情绪变化、天气、季节、气压、食物、药物)的情况下,脑内疼痛调节的细胞功能不稳定,对各种刺激敏感,产生头痛、怕光、怕响声、怕闻气味等症状。因为是神经细胞的一过性不稳定,故头痛和其他症状多是持续数小时至数天,不会长时间存在,但会反复发作。

偏头痛有哪些特点

偏头痛没有任何客观指标,所以无需做任何辅助检查。偏头痛的特点有:

1)头痛部位在偏侧,也可以在双侧,但始终固定于一侧比较罕见;

2)头痛性质多为搏动样跳痛,也可为刺痛、钻痛或炸裂样痛等,很少是钝痛或隐痛;

3)头痛程度为中-重度(0分为不痛,10为最痛,则多在4分以上);

4)头痛持续时间,成年人4-72小时,儿童可以在1小时;

5)头痛可因日常活动(走路、说话)而加重,且多伴恶心/呕吐和(或)怕光/怕响声。

偏头痛自儿童和青少年始起病,30-40岁达到发病高峰,绝经期后发作逐渐减少。

偏头痛发作除头痛外,可有多种特别表现。如有些患者在头痛前有视物模糊、手或面部麻木等,一般不超过1小时,称之为先兆。儿童患者在早期(学龄前或发育前)可表现为无诱因的反复腹痛、不明原因的周期性呕吐、发作性头晕眩晕等。

偏头痛患者容易有头晕、眩晕发作,特别容易有晕动征(晕车晕船),绝经期后患者头痛发作减少,但眩晕发作增加。

偏头痛有何危害

WHO将严重偏头痛导致的功能残疾定义为Ⅶ级,与肿瘤终末期、四肢瘫、严重抑郁及活动性精神病相同。就全球各种疾患负担的排序而言,偏头痛是前第19位。在各类神经精神疾病中,偏头痛排在严重精神疾患、痴呆、脑卒中和外伤之后,但在癫痫、多发性硬化和帕金森病之前。

大量研究显示,偏头痛人群容易伴有其他疾病,如抑郁/焦虑(约半数偏头痛患者终身会罹患)、癫痫、失眠、不明原因晕厥、脑卒中(是普通人群的2-3倍,尤其是中青年人群)、40%有卵圆孔未闭、脑的结构改变(脑白质病变和腔隙样病灶是普通人群的3-4倍)等。最重要的是,这些共病与偏头痛的发作频繁密切相关。

偏头痛了该怎么办

虽然偏头痛常见且有很大的危害性,但科学的管理可以非常有效地减少发作、减少危害。

首先,要知晓自己是否有偏头痛。做头痛日记是非常好的方法,把每次头痛的部位、性质、程度、伴随症状、持续时间、有无诱发因素完整记录,特别有助于诊断,也有助于对治疗干预的疗效判断。

其次,确立健康的生活方式,如睡眠规律、饮食规律、学会减压、加强体能活动等,可以避免诱因和减少发作。重要的是,这是不花一分钱终身获益的事哦。

偏头痛药物治疗包括两方面:发作急性期治疗和预防治疗。

发作急性期治疗的目的是快速和持续止痛、减少本次头痛再发、尽快恢复功能以减少发作导致的功能损害(旷工、旷学、影响家务或社交)、减少医疗资源浪费(看急诊、大量不必要的检查和输液)。

常用药物包括:

①解热镇痛药,对乙酰氨基酚、阿司匹林、布洛芬、萘普生等及其复方制剂;

②甲氧氯普胺、多潘立酮等止吐和促进胃动力药物不仅能治疗伴随症状,还有利于止痛剂的吸收;

③曲坦类药物,为5-羟色胺1B/1D受体激动剂,能特异地控制偏头痛,目前国内有舒马曲坦、佐米曲坦和利扎曲坦;

④麦角胺类,如麦角胺咖啡因合剂。

偏头痛发作频繁、急性发作症状严重的患者需要进行偏头痛预防治疗。通常要治疗1-2月,通过头痛日记来判断疗效,有效者需要连续治疗6个月。有循证医学证据的药物包括:

①钙离子拮抗剂:氟桂利嗪(尼莫地平无效);

②抗癫痫药:丙戊酸、托吡酯;

③抗抑郁剂:文拉法辛、阿米替林、多塞平;

④β阻滞剂:普萘洛尔、倍他乐克。慢性偏头痛者,还可以予以肉毒毒素注射。

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    2017-05-10 dhzzm

    学习了分享了

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    2017-05-10 1ddf3e1dm99(暂无匿称)

    学习了谢谢分享

    0

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    2017-05-10 王国安

    偏头痛是常见病,治疗有时棘手。

    0

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    2017-05-10 184****9840

    偏头痛很常见,学习了。

    0

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    2017-05-10 有备才能无患

    头痛在门诊确实是比较棘手的病证

    0

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    2017-05-10 1e0f8808m18(暂无匿称)

    偏头痛的研究,学习了。

    0

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    2017-05-10 130****4638

    偏头痛确实很常见,学习了。

    0

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    2017-05-09 清风拂面

    偏头痛很常见,文章总结得很好,谢谢!

    0

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    2017-05-09 医艺依意

    学习了,谢谢分享

    0

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