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在SLE患者中 羟氯喹增加甲流疫苗免疫效力

2012-04-20 邵佩 陈颖娟 中国医学论坛报

  巴西一项研究显示,SLE患者接受免疫抑制治疗可降低甲型H1N1流感疫苗效力,但羟氯喹(CQ)可能会恢复患者的免疫原性。论文1月31日在线发表于《风湿病学》(Rheumatology)杂志。   该研究显示,与健康对照相比,泼尼松(PRED)、免疫抑制剂(IS)及PRED+IS治疗组SLE患者注射甲型H1N1流感疫苗后的血清转换率较低(P<0.0001),但CQ治疗组及未治疗组患者无显著差异。

  巴西一项研究显示,SLE患者接受免疫抑制治疗可降低甲型H1N1流感疫苗效力,但羟氯喹(CQ)可能会恢复患者的免疫原性。论文1月31日在线发表于《风湿病学》(Rheumatology)杂志。

  该研究显示,与健康对照相比,泼尼松(PRED)、免疫抑制剂(IS)及PRED+IS治疗组SLE患者注射甲型H1N1流感疫苗后的血清转换率较低(P<0.0001),但CQ治疗组及未治疗组患者无显著差异。若上述前3种治疗方案同时加用CQ,则各组患者血清转换率与未治疗组无显著差异。



    

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