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J Aller Cl Imm-Pract:与儿童哮喘严重程度相关的因素

2020-12-28 MedSci原创 MedSci原创

该研究的数据表明影响哮喘严重程度的因素可能因年龄而异。在患有SRW的学龄前儿童中,二手烟和霉菌暴露是主要因素,而相关的过敏性疾病则主要与学龄期患儿SA有关。

儿童严重哮喘(SA)是一种复杂的异质性疾病,但是,影响哮喘严重程度的因素尚未明却,并且可能因年龄而异。近日,过敏性疾病领域权威杂志Journal of Allergy and Clinical Immunology-In Practice上发表了一篇研究文章,该研究旨在明确重度复发性喘息(SRW)学龄前儿童和伴有SA的学龄儿童之间哮喘严重程度相关因素是否存在差异。

该研究的数据来自法国多中心前瞻性观察队列,该研究纳入了学龄前(3-6岁)SRW患儿和非重度复发性喘息(NSRW)患儿,以及学龄期(7-11岁)SA患儿和非严重性哮喘(NSA)儿童,并进行分析。

该研究纳入了131名学龄前儿童(92名SRW和49名NSRW)和207名学龄儿童(92名SA和115名NSA)。在单变量和多变量分析中,SRW与二手烟暴露(多变量分析OR[95%CI]为29.8 [3.57-3910])和在家中霉菌/潮湿暴露有关(多变量分析:OR[95%CI]为4.22 [1.25-18.2])。在学龄期患儿中,SA患儿过敏性皮炎和食物过敏史要比NSA患儿高。多变量分析证实SA与食物过敏史相关(OR为5.01 [2.23-11.9])。

由此可见,该研究的数据表明影响哮喘严重程度的因素可能因年龄而异。在患有SRW的学龄前儿童中,二手烟和霉菌暴露是主要因素,而相关的过敏性疾病则主要与学龄期患儿SA有关。

原始出处:

Guillaume Lezmi,et al.Factors associated with asthma severity in children: data from the French COBRAPed Cohort. J Aller Cl Imm-Pract. 2019.https://doi.org/10.1016/j.jaip.2020.12.027

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    2020-12-29 膀胱癌
  3. [GetPortalCommentsPageByObjectIdResponse(id=1295972, encodeId=5a8d12959e2f7, content=<a href='/topic/show?id=5d41282361d' target=_blank style='color:#2F92EE;'>#儿童哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28236, encryptionId=5d41282361d, topicName=儿童哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Tue Dec 29 10:30:06 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329449, encodeId=c956132944918, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue Dec 29 10:30:06 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911604, encodeId=cc6b91160424, content=与儿童哮喘严重程度相关的的因素有这么多。日常生活需注意。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Mon Dec 28 14:14:42 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
    2020-12-28 Jessie Zhang

    与儿童哮喘严重程度相关的的因素有这么多。日常生活需注意。

    0

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