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2018年“延长寿命+抗衰老”成果TOP15、删除一段DNA,逆转小鼠“性别”……|BioWeek一周事

2018-06-24 佚名 生物探索

本周,2018年“延长寿命+抗衰老”成果TOP15;“绕开”淀粉样蛋白,科学家们正在寻找老年痴呆新病因;Science重大突破:删除一段DNA,逆转小鼠“性别”;PNAS:基因缺陷如何导致先天性心脏畸形;有力证据!高水平维生素D或能降低患癌风险……更多资讯,请跟随小编一起回顾吧。

1

研究动态

2018年“延长寿命+抗衰老”成果TOP15!(肠道细菌、自噬、运动、热量限制……)



逆转衰老、延长寿命相关的研究一直备受瞩目。2018年上半年,来自全球的科学家们陆续在Nature、Cell等杂志上发表了多项成果,包括增强自噬水平延长哺乳动物寿命、新化合物让小鼠“返老还童”、长期运动延缓衰老、调节肠道微生物延长果蝇寿命等。以下,就随小编一起回顾前半年的研究进展吧!

“绕开”淀粉样蛋白,科学家们正在寻找老年痴呆新病因



作为一种常见的神经性衰退疾病,阿尔兹海默症(AD)起病隐袭、多发于中老年群体。不少学者认为,β-淀粉样蛋白是AD一级预防的理想目标。现在,一篇新研究提出了不同的看法,来自于纽约州立大学布法罗分校的科学家们找到了另一种关键蛋白,有望在AD早期防治中发挥作用。

Science重大突破:删除一段DNA,逆转小鼠“性别”!



调节一个“DNA开关”,让男性变成女性?科学家们已经在小鼠身上实现了这一“听起来很科幻”的事情!相关成果发表在最新一期的Science杂志上。

人类的基因到底有多少个?近20年学界“大争议”带来最新结论| Nature



早在2000年,人类基因组序列草图还在制作中时,遗传学家们就开始对人类基因数目进行估算。近20年后,拥有真实数据的他们仍然无法就这一数量达成一致,这一知识差距阻碍了他们在发现与突变相关疾病上的努力。直至最近,科学家们又发布了最新数据:他们认为人类共有超过2.1万个蛋白质编码基因。

PNAS:基因缺陷如何导致先天性心脏畸形



下一代测序与基因编辑技术的快速发展带来了心脏病学领域的不断突破。先前的研究发现,最常见的出生缺陷类型——心脏缺陷可由CHD4基因突变引起。近日,来自美国的一项最新研究揭示了CHD4突变如何导致心脏缺陷的关键分子细节。

有力证据!高水平维生素D或能降低患癌风险



不久前,发表在BMJ上的一篇论文证实,一项针对日本成年人的大型研究发现,高水平的维生素D可能与患癌(包括肝癌)风险降低有关。本周,又有新成果证明了血液中的维生素D水平与患癌风险之间的关联!

一颗药丸模拟一场减肥手术?科学家的奇思妙想,有望治疗2型糖尿病



“胃旁路手术”(Roux-en-Y gastric bypass,RYGB)是全球最常见的减肥手术之一,但是毕竟是一个手术,所以很少有患者愿意接受这一方案。现在,科学家们研发出一种特殊药丸,可以在大鼠体内模拟手术治疗的效果,实现对血糖的控制。

Nature推翻旧论:胰腺癌患者日益消瘦,另有原因……



很多胰腺癌患者会在生病的早期日渐消瘦。过去的观点大多认为,这一症状意味着病情的加重。现在,《Nature》期刊发表一项重磅研究揭示了“癌症患者体重下降”现象的真正原因,并表明体重减轻不一定会影响患者的生存。

突破!抑制这11个基因靶点,可阻止活细胞中99.5%的癌转移 |Nature子刊



癌转移是造成癌症患者死亡的主要原因。近日,阿尔伯塔大学(University of Alberta)的研究人员发现,通过抑制几个新发现的基因靶点,可以阻止活细胞中99.5%的癌症转移。

Cell:如何让免疫疗法更有效?基因检测了解一下!



免疫疗法的成功给癌症治疗带来了新的希望。不过,这类革命性的疗法目前只能在部分患者中“奏效”。如何找到这些“响应者”是科学家们正在积极解决的问题。在近日发表的1篇Cell论文中,密歇根大学的研究团队取得一项新进展——用基因检测鉴定出能够获益于免疫疗法的前列腺癌患者。

2

产业动态

专访 | 派森诺董事长孙子奎:从“科研服务”到“健康医学”,基因测序企业的拓展之路



2003年,他选择创业,先后成立两家企业。如今,作为上海派森诺生物科技股份有限公司的董事长,他带领公司完善从一代到三代测序平台的构建,实现新三板挂牌,完成从科研服务到健康医学的转型,成功建立医学检验所、入驻国家健康医疗大数据(南京)中心……近日,生物探索专访到了在基因测序行业“崭露头角”的掌门人孙子奎。

【第一现场】中国首个肝细胞癌经动脉化疗栓塞(TACE) 术式指南正式发布



6月14日,在2018年中国医师协会介入医师分会年会(CCI 2018)于南京召开期间,《中国肝细胞癌经动脉化疗栓塞(TACE)治疗临床实践指南》正式发布。这份首个反映中国患者特点及需求的TACE治疗临床实践指南将推动我国介入治疗在肝癌领域的规范化与标准化,并促进介入医学学科的健康发展。

官方发布!公立医院可将部分服务委托给第三方医疗机构



6月19日,国家卫生健康委员会发布了《关于进一步改革完善医疗机构、医师审批工作的通知》。《通知》明确指出,在保障医疗质量安全的前提下,医疗机构可以委托独立设置的医学检验实验室、病理诊断中心、医学影像诊断中心、医疗消毒供应中心或者有条件的其他医疗机构提供医学检验、病理诊断等服务。

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    2018-12-22 sunylz
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    2018-06-24 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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    2018-06-24 明月清辉

    谢谢分享.学习了

    0

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    2018-06-24 1e17414fm02(暂无匿称)

    学习

    0

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