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Cell Metab:甘露糖水平可预测糖尿病风险 与体重无关

2016-06-29 佚名 生物谷

根据瑞典科学家们的一项最新研究,你体内的甘露糖水平可能会告诉你是否有发生2型糖尿病或胰岛素抵抗的风险,并且这种风险与是否超重无关。甘露糖作为一种单糖分子出现在许多种天然多糖中,这项最新研究还发现其可以成为预测糖尿病风险的生物标记物。相关研究结果发表在国际学术期刊Cell Metabolism上。文章作者这样说道:“我们可以测量瘦人和胖人血液中的甘露糖水平,基于甘露糖水平判断其是否有患2型糖尿病的风


根据瑞典科学家们的一项最新研究,你体内的甘露糖水平可能会告诉你是否有发生2型糖尿病或胰岛素抵抗的风险,并且这种风险与是否超重无关。甘露糖作为一种单糖分子出现在许多种天然多糖中,这项最新研究还发现其可以成为预测糖尿病风险的生物标记物。相关研究结果发表在国际学术期刊Cell Metabolism上。

文章作者这样说道:“我们可以测量瘦人和胖人血液中的甘露糖水平,基于甘露糖水平判断其是否有患2型糖尿病的风险。“

研究人员发现甘露糖水平较高的人患2型糖尿病的风险也更高。文章作者表示由于血液中甘露糖水平非常稳定,不会像血液中的葡萄糖水平一样受到进食等因素的影响,因此甘露糖可以用作生物标记物。

研究人员表示这项研究让我们重新思考了肥胖与糖尿病之间的假定关系。“虽然肥胖和2型糖尿病在全世界范围内越来越流行,但是对于隐藏在其中的分子学机制仍然缺少清晰认识。找到能够用于早期发现胰岛素抵抗和预测2型糖尿病风险的稳定的生物标记物是非常重要的事情。”

在这项研究中研究人员使用了基于系统生物学的方法,构建了细胞特异性的整合网络,他们使用了这些生物学网络分析临床数据来揭示肥胖和胰岛素抵抗过程中的生物学变化,为深入发现肥胖与糖尿病的关系提供了全面的分子线索。

基于这些整合分析,研究人员认为这些信息对于临床预测2型糖尿病风险非常有用,但是还需要更大型的研究进一步对这些结果进行临床验证。

原始出处

Sunjae Lee1, 11, Cheng Zhang1, 11, Murat Kilicarslan2.Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.Cell Metab.2016

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    2016-07-13 一闲
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    2017-06-06 维他命
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    2016-11-29 guojianrong
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