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J Dent Res:绝经后妇女,骨密度还影响牙周附着?

2017-03-19 MedSci MedSci原创

骨质疏松是全身性骨骼疾病,主要特征是低骨密度,它已被认为是牙周疾病的危险因素。这篇系统综述及meta分析主要在于证实绝经后妇女牙周附着丧失与低骨密度相关性的科学依据。

骨质疏松是全身性骨骼疾病,主要特征是低骨密度,它已被认为是牙周疾病的危险因素。这篇系统综述及meta分析主要在于证实绝经后妇女牙周附着丧失与低骨密度相关性的科学依据。

参照以往发表的系统综述以及meta(PRISM)分析指南,在数据库对截止至2016年8月的相关文献进行系统搜索,纳入标准为对绝经后低骨密度及正常骨密度的临床附着丧失情况进行比较的研究,采用相似的方法论、具有较低和较高风险偏见的研究都合并成3个不同的meta分析,对具有正常骨密度、骨质疏松和骨量减少妇女的临床牙周附着进行比较。在第一个meta分析中,对组间平均临床附着丧失进行比较。在其余两个meta分析中,则对临床附着丧失≥4mm及临床附着丧失≥6mm位点百分比分别进行组间比较。在792篇独立引文中,26篇文章被纳入进行定性分析,其中11篇文章被评估为存在偏见低风险,这些文章则有10篇观察到低骨密度和临床附着丧失的相关性。13篇横断面研究的文章被纳入进行骨质疏松的meta分析,9篇被纳入进行骨量减少的分析。

相比于具有正常骨密度的女性,低骨密度的女性呈现出更高的平均临床附着丧失,即:骨质疏松患者的临床附着丧失=0.34mm(95%的置信区间为:0.20-0.49),p<0.001;骨量减少患者的临床附着丧失=0.07mm(95%的置信区间为:0.01-0.13),p=0.02。对于临床附着丧失严重度分析,仅有偏见低风险的研究有效。对临床附着丧失≥4mm位点百分比进行比较,骨质疏松患者=3.04(95%的置信区间为:1.23-4.85),P = 0.001,骨量减少患者=1.74(95%的置信区间为:0.36-3.12),P =0.01;对临床附着丧失≥6mm位点百分比进行比较,骨质疏松患者=5.07(95%的置信区间为:2.74-7.40),P < 0.001,由此说明低骨密度的女性表现出更严重的附着丧失。

这篇系统综述及meta分析表明:相比于具有正常骨密度的绝经后妇女,骨质疏松和骨量减少的绝经后妇女可能呈现出更明显的平均临床附着丧失

原始出处:

Penoni DC, et al. Bone Density and Clinical Periodontal Attachment in Postmenopausal Women. J Dent Res. 2017 ;96(3):261-269. doi: 10.1177/0022034516682017.

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    2017-03-23 往日如昨

    低骨密度的女性表现出更严重的附着丧失。

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=182184, encodeId=76ec18218400, content=低骨密度的女性表现出更严重的附着丧失。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Thu Mar 23 13:37:30 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257086, encodeId=2e30125e0865e, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332000, encodeId=65ee1332000dc, content=<a href='/topic/show?id=0ab6e8887cc' target=_blank style='color:#2F92EE;'>#绝经后妇女#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78887, encryptionId=0ab6e8887cc, topicName=绝经后妇女)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18b32500069, createdName=108807375_62823127, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450499, encodeId=16f71450499b9, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631537, encodeId=3c6d163153e2c, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181271, encodeId=040e1812e194, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 20 00:06:17 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181244, encodeId=628e181244e7, content=骨质疏松是全身性骨骼疾病,主要特征是低骨密度, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Sun Mar 19 22:27:55 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-21 zxxiang
  6. [GetPortalCommentsPageByObjectIdResponse(id=182184, encodeId=76ec18218400, content=低骨密度的女性表现出更严重的附着丧失。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Thu Mar 23 13:37:30 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257086, encodeId=2e30125e0865e, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332000, encodeId=65ee1332000dc, content=<a href='/topic/show?id=0ab6e8887cc' target=_blank style='color:#2F92EE;'>#绝经后妇女#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78887, encryptionId=0ab6e8887cc, topicName=绝经后妇女)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18b32500069, createdName=108807375_62823127, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450499, encodeId=16f71450499b9, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631537, encodeId=3c6d163153e2c, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181271, encodeId=040e1812e194, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 20 00:06:17 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181244, encodeId=628e181244e7, content=骨质疏松是全身性骨骼疾病,主要特征是低骨密度, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Sun Mar 19 22:27:55 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-20 飛歌

    学习了很有用

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=182184, encodeId=76ec18218400, content=低骨密度的女性表现出更严重的附着丧失。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Thu Mar 23 13:37:30 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257086, encodeId=2e30125e0865e, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332000, encodeId=65ee1332000dc, content=<a href='/topic/show?id=0ab6e8887cc' target=_blank style='color:#2F92EE;'>#绝经后妇女#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78887, encryptionId=0ab6e8887cc, topicName=绝经后妇女)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18b32500069, createdName=108807375_62823127, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450499, encodeId=16f71450499b9, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631537, encodeId=3c6d163153e2c, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Tue Mar 21 10:51:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181271, encodeId=040e1812e194, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 20 00:06:17 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181244, encodeId=628e181244e7, content=骨质疏松是全身性骨骼疾病,主要特征是低骨密度, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Sun Mar 19 22:27:55 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-19 Albert Wu

    骨质疏松是全身性骨骼疾病,主要特征是低骨密度

    0

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通过测定血清25羟维生素D(S-25OHD)判断骨骼健康情况时,肯定会存在一个阈值,那么季节是否会对这个阈值产生影响呢?是否应该在不同季节选择不同的阈值呢? 因此我们进行了本项研究,探究使用S-25OHD评估骨密度(BMD)时,季节会对其产生怎样的相对影响? 研究纳入了5002名瑞典妇女(平均年龄68岁),来自于一项以人群为基础的大型纵向队列研究,所有参与者都有重复测量的饮食和生活方式

JAMA Intern Med:人年纪大了缩小了——这是脆性骨折!

脆性骨折是指无外伤或轻微外伤情况下引起的骨折。所谓轻微外伤,一般指在平地或身体重心高度跌倒所引起损伤。脆性骨折多发生在老年人,是骨质疏松症的最严重后果,所以又称骨质疏松性骨折。脆性骨折主要发生于胸椎、腰椎、髋部及前臂。发生椎体压缩性骨折,不仅影响身高而且还会腰疼,但有的人自己都不知道,以为是人老了就“缩”了。髋部骨折后果最为严重,一年内有20%的病人因并发症死亡,30%有永久残疾,40%的人不能独

JAMA Oncol:儿童癌症幸存者骨密度低,低幅高频机械刺激来帮你

在青少年时期,骨骼自然生长是至关重要的,这样能够为终生的骨骼健康提供充足的力量。患有癌症的儿童可能会在诊断前后出现骨密度(BMD)偏低的现象。该研究的目的是评估使用低幅,高频机械刺激来提高儿童癌症幸存者骨密度的能力。从2010年6月1日到2013年1月22日,来自美国的研究人员在圣裘德儿童研究医院进行了一项双盲随机临床试验,该研究纳入了7岁至17岁的癌症幸存者,这些患者曾经在圣裘德儿童研究医院进行

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