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Int J Oral Max Surg:口腔癌术前放化疗对于患者咀嚼、唾液和吞咽功能的重要性:对生活质量的前瞻性研究

2017-09-19 MedSci MedSci原创

这项研究的主要目的是使用两个经过验证的问卷调查,调查口腔鳞状细胞癌(OSCC)患者接受治疗性新辅助放化疗,之后进行根治性肿瘤切除术,同时口腔重建后的生活质量(QOL)。第二个目标是评估临床变量预测治疗后咀嚼,唾液和吞咽的功能障碍的效果。

这项研究的主要目的是使用两个经过验证的问卷调查,调查口腔鳞状细胞癌(OSCC)患者接受治疗性新辅助放化疗,之后进行根治性肿瘤切除术,同时口腔重建后的生活质量(QOL)。第二个目标是评估临床变量预测治疗后咀嚼,唾液和吞咽的功能障碍的效果。

前瞻性地招募了35例接受术前放化疗的局部晚期OSCC患者。所有患者均完成了华盛顿大学生命质量第4版问卷调查(UW-QOL)和头颈癌症治疗功能评估的第4版问卷调查问卷(FACT-H&N)。 UW-QOL和FACT-H&N项目与临床变量相关。近四分之三的OSCC患者术前放化疗后的总体生活质量水平在感觉良好到好之间。咀嚼困难,唾液功能下降和吞咽功能障碍是OSCC患者生活中最常见的问题。60岁以上的患者,T4患者以及不喝酒的患者,食物摄入困难明显。咀嚼,唾液和吞咽是OSCC术前放化疗的最重要的问题。本研究的结果可能有助于根据对癌症治疗不良反应更准确地预测,来指导OSCC患者的治疗决策。

原始出处:

D. Nemeth, L. Zaleczna, A. Huremovic, et al. Importance of chewing, saliva, and swallowing function in patients with advanced oral cancer undergoing preoperative chemoradiotherapy: a prospective study of quality of life. International Journal of Oral and Maxillofacial Surgery. 2017 October. doi: 10.1016/j.ijom.2017.05.005

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    2018-06-23 小几洁
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time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245944, encodeId=0d412459447d, content=厉害厉害--学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed Sep 20 09:12:41 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245910, encodeId=a6b1245910dc, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Sep 20 07:49:58 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245878, encodeId=83c02458e8e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Sep 20 06:56:00 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2018-06-17 Boyinsh
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    2018-08-06 mgqwxj
  7. 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createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Sep 20 07:49:58 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245878, encodeId=83c02458e8e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Sep 20 06:56:00 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-21 yzh399
  8. 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time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245944, encodeId=0d412459447d, content=厉害厉害--学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed Sep 20 09:12:41 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245910, encodeId=a6b1245910dc, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, 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    2017-09-20 尹玉伟

    厉害厉害--学习了

    0

  9. 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createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Sep 20 07:49:58 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245878, encodeId=83c02458e8e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Sep 20 06:56:00 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 Y—xianghai

    学习了新知识

    0

  10. 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createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Sep 20 07:49:58 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245878, encodeId=83c02458e8e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Sep 20 06:56:00 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 明月清辉

    谢谢分享.学习了

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