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Diabetes Care:糖尿病加重慢性心力衰竭患者的不良预后!

2017-03-05 MedSci MedSci原创

糖尿病与心血管疾病(CVD)和死亡的风险增加相关。由于糖尿病的患病率在全球范围内逐年上升,慢性心力衰竭(CHF)随着人口老龄化也越来越普遍。因此,应及时评估糖尿病对CHF患者1年不良预后的影响。近期,一篇发表在杂志Diabetes Care上的文章对这一问题进行了研究。研究者们前瞻性地评估了9,428名登记在欧洲心脏病学和心力衰竭协会的CHF患者出现糖尿病状态是否独立影响1年的全因死亡和CVD死亡

糖尿病与心血管疾病(CVD)和死亡的风险增加相关。由于糖尿病的患病率在全球范围内逐年上升,慢性心力衰竭(CHF)随着人口老龄化也越来越普遍。因此,应及时评估糖尿病对CHF患者1年不良预后的影响。


近期,一篇发表在杂志Diabetes Care上的文章对这一问题进行了研究。

研究者们前瞻性地评估了9,428名登记在欧洲心脏病学和心力衰竭协会的CHF患者出现糖尿病状态是否独立影响1年的全因死亡和CVD死亡的风险,是否影响第一次住院的恶化心力衰竭(HF)。

此项研究结果显示:与那些没有糖尿病的患者相比,糖尿病患者(n = 3,440,36.5%)1年全因死亡的累积率(9.4%vs. 7.2%;校正风险比[HR] 1.28; 95%CI 1.07 -1.54),CVD死亡(4.8%比3.8%;调整HR 1.28; 95%CI 0.99-1.66)和HF住院治疗(13.8%比9.3%;调整HR 1.37; 95%CI 1.17-1.60)均较高,上述指标均独立于年龄,性别,BMI,吸烟,收缩压,估计的肾小球滤过率,血红蛋白,HF病因,左心室射血分数,高血压,他汀类药物使用和既往中风或慢性阻塞性肺病。在基线时测量HbA1c的CHF患者(n = 2,567)中,HbA1c水平增高与1年生存结果的风险之间存在显着且独立的关联。

此项研究表明:合并糖尿病显着增加了患有CHF的门诊患者1年不良临床结果的风险,并且与多个常见的风险因素无关。在此高风险的患者群体中应考虑更有效和个性化的糖尿病治疗。

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    2017-03-07 Dr.jerry

    谢谢分享

    0

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    2017-03-06 1e0ece0dm09(暂无匿称)

    谢谢分享

    0

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