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Nat Commun:新发现!人类即将远离感冒!

2017-02-25 老三老四 来宝网

【科学家几乎成功破解了感冒病毒的 “隐藏密码”】 近日,约克、利兹和赫尔辛基大学的科学家在国际顶级期刊《Nature Communications》上发表了一项研究成果,他们在研究过程中几乎破解了普通感冒病毒的致病的 “隐藏密码”。人双埃可病毒是小核糖核酸病毒家族中的一员,能引发普通感冒、小儿麻痹症和手足口病等疾病。这些科学家的研究成功揭示了人双埃可病毒基因中引发疾病的致病机制。这项研究成果源于

【科学家几乎成功破解了感冒病毒的 “隐藏密码”】 近日,约克、利兹和赫尔辛基大学的科学家在国际顶级期刊《Nature Communications》上发表了一项研究成果,他们在研究过程中几乎破解了普通感冒病毒的致病的 “隐藏密码”。

人双埃可病毒是小核糖核酸病毒家族中的一员,能引发普通感冒、小儿麻痹症和手足口病等疾病。这些科学家的研究成功揭示了人双埃可病毒基因中引发疾病的致病机制。

这项研究成果源于 2015 年的一项偶然发现,科学家们发现了一种基因组为单链 RNA 的植物病毒,它的结构跟人双埃可病毒类似,也能引发感染,使儿童产生脑膜炎和败血症样症状。随后,他们发现,所有病毒中都具有类似的基因编码区和相同的致病机制,这让使用单一药物治疗病毒感染成为了可能,人们也不在需要依赖疫苗来控制感染了。

Reidun Twarock 教授表示,“以前科学家都认为,病毒基因组中有一个特定的区域在负责调控病毒组装信号,而最新研究发现,基因组中多个分散的区域共同协作才完成了病毒的形成。每年,全球因普通感冒病毒引起的感染人数超过二十亿,这使普通感冒病毒成为病毒中的 “佼佼者”,但现在,我们的研究成功破解了它的机制,这个基因组中的隐藏区域,负责病毒的形成,但却不随病毒基因变异而改变,在同一个病毒家族中也保持一致。这就给了我们一个破坏病毒形成的机会,我们可以找到一种药物直接把病毒破坏了。普通感冒也有望被攻克!”

Sarah Butcher 教授也兴奋地认为,“利用这项新成果研发的药物可能不会引起病毒耐药性,这也是目前抗感染领域的一大难题,这项成果是该领域的重大突破!”

现在,这些科学家已经开始利用自己的发现来研发新的抗病毒药物。通过加深与制药公司的合作,以及进一步的研发资助下,这种抗病毒的新药有望在未来的十年内研发成功。

原始出处
Shabih Shakeel,Eric C. Dykeman,Simon J. White,et al.Genomic RNA folding mediates assembly of human parechovirus.Nature Communications 8,Article number:5 (2017)

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    2017-05-14 liye789132251
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    2017-03-15 liuli5079
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    2017-02-27 吴教授

    不同的病毒具有一段相同的碱基,具有相同的治病机制

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