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Stroke:肺切除术和肺叶切除术后卒中的发生率

2019-04-08 xing.T 网络

由此可见,接受全肺切除术或肺叶切除术的患者术后30天卒中风险增加。肺静脉残端是否是卒中的危险因素以及预防策略是否相关需要进一步调查。

肺切除术或肺叶切除术后,至少留有1处肺静脉残端,其具有术后血栓栓塞事件的潜在风险。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,与正常和肺楔形切除术对照者相比,研究人员旨在调查肺切除术或肺叶切除人群中的卒中风险。

研究人员使用了1996年至2016年期间丹麦全国登记处的数据,确定了12965例肺切除术或肺叶切除术患者和6400例楔形切除患者。在多变量泊松回归分析中,研究人员估计了接受肺叶切除术或全肺切除术患者与正常对照人群和接受楔形切除术患者的卒中发生率比率。研究人员将分析按天分层:术后0至30、31至90、91至180和180至365,并对肺癌患者进行亚组分析。

对于肺切除术或肺叶切除术患者,卒中发生率为每1000人每年10.6例,对于未接受全肺切除术或肺叶切除术的患者,卒中发生率为每1000人每年2.3例。在0至30天的多变量Poisson回归分析中,与正常人群相比,全肺切除术或肺叶切除术与卒中风险增加有关,房颤患者(发病率比率[IRR])为4.66(95%CI为2.04-7.12)和无房颤患者为5.43(95%CI为3.99-7.41)。同样,在肺癌患者中,对房颤患者(IRR为2.94; 95%CI为1.39-6.25)和无房颤患者(IRR为2.56; 95%CI为1.86-3.59)肺切除术或肺叶切除术后前30天仍然是发生卒中的危险因素。与楔形切除相比,肺叶切除术或全肺切除术后0至30天也与卒中风险增加有关(IRR为2.63; 95%CI为1.19-5.81);然而,这种关联在肺癌患者中无显著性(IRR为2.98; 95%CI为0.72-12.29)。

由此可见,接受全肺切除术或肺叶切除术的患者术后30天卒中风险增加。肺静脉残端是否是卒中的危险因素以及预防策略是否相关需要进一步调查。

原始出处:

Signe Riddersholm.et al.Incidence of Stroke After Pneumonectomy and Lobectomy A Nationwide, Register-Based Study.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.024496

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    2019-04-09 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2019-04-08 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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