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Chest:COVID-19与H1N1所致急性呼吸窘迫综合征住院患者的比较

2020-03-28 MedSci原创 MedSci原创

COVID-19与H1N1所致的ARDS在临床表现上存在诸多差异。与H1N1相比,COVID-19所致的ARDS患者在就诊时的疾病严重程度评分较低,经SOFA评分调整的死亡率较低。

自2019年12月,爆发2019年冠状病毒病(COVID-19)以来,对阐明其来源和表现引起了广泛关注。然而,临床医生和流行病学家将COVID-19与其他呼吸道传染病(如流感病毒)区分开来也很重要。近日,呼吸领域权威杂志chest上发表了一篇研究文章,该研究旨在探讨COVID-19与甲型H1N1流感肺炎所致的急性呼吸窘迫综合征(acute respiratory distress syndrome, ARDS)患者不同的临床表现。

这是一项回顾性的病例对照研究,研究人员比较了两组分别感染COVID-19 (n=73)和H1N1 (n=75)的ARDS患者,并分析比较了他们的临床表现、影像学特点、治疗方法和预后。

COVID-19患者的中位年龄高于H1N1患者,且COVID-19患者中男性比例较高(p<0.05)。COVID-19患者无痰干咳、疲劳和胃肠道症状所占比例高于H1N1患者(p<0.05)。H1N1患者的序贯器官衰竭估计评分(SOFA)评分高于COVID-19患者(p<0.05)。COVID-19患者的PaO2/FiO2 (1980.2 mmHg)明显高于H1N1患者的PaO2/FiO2 (107.0 mmHg) (p<0.001)。与H1N1患者相比,COVID-19患者CT上毛玻璃样混浊更常见(p<0.001)。与H1N1患者相比,COVID-19患者有更多种类的抗病毒治疗。COVID-19患者的住院死亡率为28.8%,而H1N1患者的住院死亡率为34.7% (p=0.483)。SOFA评分调整后的死亡率H1N1患者明显高于COVID-19患者,其比率为2.009 (95%CI为[1.563, 2.583],p<0.001)。

由此可见,COVID-19与H1N1所致的ARDS在临床表现上存在诸多差异。与H1N1相比,COVID-19所致的ARDS患者在就诊时的疾病严重程度评分较低,经SOFA评分调整的死亡率较低。

原始出处:

Xiao Tang,et al.Comparison of Hospitalized Patients with Acute Respiratory Distress Syndrome Caused by COVID-19 and H1N1.chest.2020.https://journal.chestnet.org/article/S0012-3692(20)30558-4/fulltext

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    2020-04-17 Smile2680
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    2020-03-30 TZF0806
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