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J Clin Periodontol:牙周炎对急性冠状动脉综合征患者全身性炎症的影响

2016-03-30 MedSci MedSci原创

目前,急性冠状动脉综合征与牙周炎之间的因果关系尚未确定。本研究旨在评估伴有或不伴有急性冠状动脉综合征或同时伴有牙周炎的患者血清细胞因子水平的差异。

目前,急性冠状动脉综合征与牙周炎之间的因果关系尚未确定。本研究旨在评估伴有或不伴有急性冠状动脉综合征或同时伴有牙周炎的患者血清细胞因子水平的差异。

在此病例对照研究中,研究共纳入了患有78名急性冠状动脉综合征(10.3%为女性)以及78名健康人群( 28.2%为女性)。已完成医疗和牙科检查以确诊急性冠状动脉综合征和牙周炎。采用Luminex技术评估所有研究对象的血清细胞因子水平。

结果发现,急性冠状动脉综合征患者和对照组诊断为牙周炎的人数比例分别为52.6%和12.8%。未校正比值比,急性冠状动脉综合征同时伴有牙周炎的比值比为7.5。不考虑牙周状况、急性冠状动脉综合征患者的血清白介素-8和血管内皮生长因子(VEGF)的水平显著高于对照组。诊断为牙周炎的急性冠状动脉综合征患者的患者血清中细胞因子的表达则无差异。

总而言之,血清中血管内皮生长因子的水平升高与急性冠状动脉综合征有关。急性冠状动脉综合征患者血清中细胞因子的表达与患者的牙周状况无关。

原始出处:

Widén C, Holmer H, Coleman M, Tudor M, Ohlsson O, Sättlin S, Renvert S, Persson GR. Systemic inflammatory impact of periodontitis on acute coronary syndrome. J Clin Periodontol. 2016 Mar 3. doi: 10.1111/jcpe.12540.

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    2017-01-28 feather89
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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2016-09-12 ylzr123

    赞了!深度好文,学习。

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