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Circulation:B型主动脉夹层治疗:如何选择?

2015-09-30 张旭栋 MedSci原创

休斯敦德克萨斯大学医学院Afifi RO等人研究了B型主动脉夹层患者的远期结局,成果发表在8月份Circulation期刊上。背景:主动脉夹层(Aortic Dissection,AD)是最主要的主动脉上的灾难性疾病。在血管腔内时代,急性B型主动脉夹层(acute type B aortic dissection, ATBAD)的治疗最引入注目。本项研究旨在评估我们中心治疗时间已经超过13年ATB

休斯敦德克萨斯大学医学院Afifi RO等人研究了B型主动脉夹层患者的远期结局,成果发表在8月份Circulation期刊上。

背景:主动脉夹层(Aortic Dissection,AD)是最主要的主动脉上的灾难性疾病。在血管腔内时代,急性B型主动脉夹层(acute type B aortic dissection, ATBAD)的治疗最引入注目。本项研究旨在评估我们中心治疗时间已经超过13年ATBAD患者的远期结局。

方法和结果:我们回顾2001年和2014年之间ATBAD患者,分析了患者的状态(患并发症[C]与不患并发症[U])和治疗方式。我们定义cATBAD为血管破裂,入院期间影像学显示血管直径扩张,持续性疼痛,或初次入院期间脑、脊髓、内脏、肾、或周围血管灌注不足。术后的结果定义为介入前不存在灌注不足。通过使用Kaplan-Meier法和描述性统计数据对组内的结局进行比较。我们治疗了442例ATBAD患者。442例患者中,60.6%患有uATBAD,39.4%患有cATBAD。cATBAD患者中39.0%的患者进行医学处理,30.0%患者进行开放性修复,21.3%进行胸主动脉腔内修复,9.7%患者进行其他开放治疗。1年和5年的干预生存率,uATBAD 患者分别为84.8%和62.7%,行医学处理的cATBAD患者分别为61.8%和44.0%,行开放性修复的cATBAD患者分别为69.2%和开47.2%,行胸主动脉腔内修cATBAD患者分别为68.0%和42.5%,各组内比较分别为P = 0.001。结局显示,cATBAD患者各组治疗结局中有显著性差异。

结局:根据我们的经验,ATBAD患者早期和晚期结局都依赖于是否具有并发症,cATBAD患者所面临的结局情况更糟。X线监视下行开放性治疗或血管内介入治疗发现,尽管uATBAD具有良好的早期生存率,但晚期并发症仍然时有发生。目前仍然需要uATBAD患者最佳治疗的前瞻性研究。

原始出处:

Afifi RO, Sandhu HK, Leake SS, Boutrous ML, Kumar V, 3rd, Azizzadeh A, Charlton-Ouw KM, Saqib NU, Nguyen TC, Miller CC, 3rd, Safi HJ, Estrera AL (2015) Outcomes of Patients With Acute Type B (DeBakey III) Aortic Dissection: A 13-Year, Single-Center Experience. Circulation 132 (8):748-754. doi:10.1161/circulationaha.115.015302

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