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Stroke:缺血性卒中患者血运重建后的血压变化特点

2016-04-29 fsy 译 MedSci原创

历史卒中队列研究报告血压(BP)和临床结果之间有U形或J形关系。然而,这些研究早于目前的血运重建策略,并没有考虑到受影响的动脉的再通状态。该研究的目的是调查接受静脉或动脉内溶栓治疗患者缺血性卒中第一个24小时的BP和临床结果之间的关系。来自葡萄牙的研究人员进行了一项回顾性队列研究,该研究纳入了静脉溶栓或动脉内溶栓治疗急性脑卒中的连续患者。血压在卒中发作后第一个24小时的整个昼夜定期测量。研究人员计

过去的卒中队列研究发现血压(BP)和临床结果之间有U形或J形关系。然而,这些研究早于目前的血运重建策略,并没有考虑到受影响的动脉的再通状态。该研究的目的是调查接受静脉或动脉内溶栓治疗缺血性卒中患者后,第一个24小时的BP和临床结果之间的关系。

来自葡萄牙的研究人员进行了一项回顾性队列研究,该研究纳入了静脉溶栓或动脉内溶栓治疗急性脑卒中的连续患者。血压在卒中发作后第一个24小时的整个昼夜定期测量。研究人员计算了卒中发作后第一个24小时期间的平均收缩压和舒张压。在6小时时,再通状态通过颅彩色编码多普勒、血管造影术、或血管性计算机断层扫描进行评估。在3个月时的功能结果通过改良Rankin量表进行评估。线性和二次多元回归模型,用来确定整体人群、再通和非再通患者的BP和功能结果之间的关系。

研究人员共纳入674例患者;平均年龄为73.28岁(SD,11.50岁)。共355(52.70%)例患者记录动脉血管再通。在多变量分析中,总人群和非再通患者在卒中后第一个24h的收缩压和舒张压与功能结果呈J形关系。再通患者表现出与功能结果呈线性关系(收缩压:比值比为1.015; 95%置信区间,1.007-1.024; P = 0.001; R2变化=0.001;P=0.412,舒张压:比值比为1.019; 95%置信区间,1.004-1.033; P=0.012; R2变化<0.001,P=0.635)。P=0.412

缺血性卒中后第一个24小时的血压影响3个月的临床结果。这种关联是依赖于血运重建状态。

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    2016-04-30 Lisa971

    血运重建机理。

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