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Hypertension:抗高血压药物能延缓青光眼的发生

2016-12-07 haofan MedSci原创

尽管高血压,通过服用抗高血压药物治疗来确定,与青光眼之间存在正相关性,但是该研究的结果表明,抗高血压药物本身可能对青光眼的发生发展具有预防作用。

高血压病作为人类常见病,发病率逐年增加,抗高血压药物治疗也随之上升;青光眼,因眼内压调整功能发生障碍使眼压异常升高出现视功能障碍,是一种对视力危害极大的常见疾病,抗高血压药物能否影响青光眼尚未有文献报道。近日,心血管权威杂志Hypertension上发表一篇来自丹麦哥本哈根大学神经药理学系的Anna Horwitz教授及其研究团队的文章,旨在探讨抗高血压药物治疗对青光眼发病的影响。 

该研究的数据来自在1996年至2012年期间年龄在4095岁之间的全部的丹麦人群,该研究的参与者涵盖了260万人。研究人员通过丹麦国家药品统计登记处来确定所有声称服用青光眼处方药物和抗高血压药物的患者。 

研究人员首先分析了数据中的基本相关性,并发现接受抗高血压药物治疗的患者,在研究过程中的任何阶段,青光眼的总体相对风险显著升高,即使控制了年龄和性别(相对风险为1.31P0.0001)。此外,该研究的数据证实了年龄和青光眼之间众所周知的正相关关系。 

为了进一步探究抗高血压药物治疗对青光眼开始药物治疗之间的因果关系,研究人员采用了不连续性回归研究设计。在这一分析中,研究人员的主要发现为抗高血压药物治疗导致了患者发生青光眼的风险显著降低。 

因此,尽管高血压通过服用抗高血压药物治疗来确定与青光眼之间存在正相关性,但是该研究的结果表明,抗高血压药物本身可能对青光眼的发生发展具有预防作用。 

原始出处: 

Anna Horwitz, et al. Antihypertensive Medication Postpones the Onset of Glaucoma Evidence From a Nationwide Study. Hypertension. 2016. 

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Dec 18 15:25:26 CST 2016, time=2016-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162204, encodeId=dcdf162204ab, content=我想以后对家人这样,尽孝道, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/259E5ED39E0D4282FD78CD856729A447/100, createdBy=494c1710017, createdName=阿寿6126f9b9, createdTime=Mon Dec 12 15:50:06 CST 2016, time=2016-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162196, encodeId=65861621961d, content=药物机制相类似,所以产生了相同的效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/259E5ED39E0D4282FD78CD856729A447/100, createdBy=494c1710017, createdName=阿寿6126f9b9, createdTime=Mon Dec 12 15:46:04 CST 2016, time=2016-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501099, encodeId=4dda15010990e, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Dec 09 08:16:00 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545671, encodeId=6fca15456e168, content=<a href='/topic/show?id=a383558515b' target=_blank style='color:#2F92EE;'>#抗高血压药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55851, encryptionId=a383558515b, topicName=抗高血压药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e46713811513, createdName=ms9474365431325850, createdTime=Fri Dec 09 08:16:00 CST 2016, time=2016-12-09, status=1, ipAttribution=)]
    2017-07-12 feather89
  5. 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likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/259E5ED39E0D4282FD78CD856729A447/100, createdBy=494c1710017, createdName=阿寿6126f9b9, createdTime=Mon Dec 12 15:46:04 CST 2016, time=2016-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501099, encodeId=4dda15010990e, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Dec 09 08:16:00 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545671, encodeId=6fca15456e168, content=<a href='/topic/show?id=a383558515b' target=_blank style='color:#2F92EE;'>#抗高血压药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55851, encryptionId=a383558515b, topicName=抗高血压药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e46713811513, createdName=ms9474365431325850, createdTime=Fri Dec 09 08:16:00 CST 2016, time=2016-12-09, status=1, ipAttribution=)]
    2016-12-19 飘飘爱

    非常好的内容

    0

  6. 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likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/259E5ED39E0D4282FD78CD856729A447/100, createdBy=494c1710017, createdName=阿寿6126f9b9, createdTime=Mon Dec 12 15:46:04 CST 2016, time=2016-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501099, encodeId=4dda15010990e, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri Dec 09 08:16:00 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545671, encodeId=6fca15456e168, content=<a href='/topic/show?id=a383558515b' target=_blank style='color:#2F92EE;'>#抗高血压药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55851, encryptionId=a383558515b, topicName=抗高血压药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e46713811513, createdName=ms9474365431325850, createdTime=Fri Dec 09 08:16:00 CST 2016, time=2016-12-09, status=1, ipAttribution=)]
    2016-12-18 李东泽

    很好,不错,以后会多学习

    0

  7. 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href='/topic/show?id=a383558515b' target=_blank style='color:#2F92EE;'>#抗高血压药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55851, encryptionId=a383558515b, topicName=抗高血压药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e46713811513, createdName=ms9474365431325850, createdTime=Fri Dec 09 08:16:00 CST 2016, time=2016-12-09, status=1, ipAttribution=)]
    2016-12-12 阿寿6126f9b9

    我想以后对家人这样,尽孝道

    0

  8. 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href='/topic/show?id=a383558515b' target=_blank style='color:#2F92EE;'>#抗高血压药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55851, encryptionId=a383558515b, topicName=抗高血压药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e46713811513, createdName=ms9474365431325850, createdTime=Fri Dec 09 08:16:00 CST 2016, time=2016-12-09, status=1, ipAttribution=)]
    2016-12-12 阿寿6126f9b9

    药物机制相类似,所以产生了相同的效果

    0

  9. 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  10. 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