Kidney Int：增强干细胞在缺血再灌注肾损伤中功效的新方法！

2017-11-21 MedSci MedSci原创

研究表明，间充质干细胞（MSCs）对实验性缺血再灌注急性肾损伤（IRI-AKI）的治疗具有一定的效果。其中，免疫调节是MSCs治疗的重要机制之一。白细胞介素-17A（IL-17A）预处理的MSsC更具免疫抑制性，而体外免疫原性的变化很小。近期，一项发表在杂志Kidney Int上的研究旨在评估给予IL-17A-预处理的MSCs导致IRI-AKI小鼠的急性肾小管坏死评分，血清肌酐以及BUN是否显着低

研究表明，间充质干细胞（MSCs）对实验性缺血再灌注急性肾损伤（IRI-AKI）的治疗具有一定的效果。其中，免疫调节是MSCs治疗的重要机制之一。白细胞介素-17A（IL-17A）预处理的MSsC更具免疫抑制性，而体外免疫原性的变化很小。近期，一项发表在杂志Kidney Int上的研究旨在评估给予IL-17A-预处理的MSCs导致IRI-AKI小鼠的急性肾小管坏死评分，血清肌酐以及BUN是否显着低于给予MSCs。此项研究结果显示：在共培养的脾细胞中，IL-17A预处理的MSCs显着增加了CD4 + Foxp3 + Tregs的百分比，降低了concanavalin A诱导的T细胞增殖。此外，与接受MSCs治疗的小鼠相比，接受IL-17A预处理的MSCs治疗的IRI-AKI小鼠的血清IL-6、TNF-α和IFN-γ水平显着降低，而血清IL-10水平更高，脾脏和肾脏Treg的百分比也更高。由PC61（抗-CD25抗体）对Treg的消耗逆转了IL-17A-预处理的MSCs对IRI-AKI小鼠增强的治疗功效。另外，IL-17A还上调了COX-2的表达并增加了PGE2的产生。塞来昔布阻断COX-

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#插入话题

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2018-11-01 kord1982

#新方法#

47 0
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2017-11-23 ms3046638856685384

#损伤#

72 0
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2017-11-23 gwc389

#kidney#

50 0
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2017-11-22 儒医liu

好办法!

100 0
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2017-11-22 明天会更好！

非常好的文章.学习了!

82 0
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2017-11-21 有备才能无患

研究表明.间充质干细胞(MSCs)对实验性缺血再灌注急性肾损伤(IRI-AKI)的治疗具有一定的效果.其中.免疫调节是MSCs治疗的重要机制之一.白细胞介素-17A(IL-17A)预处理的MSsC更具免疫抑制性.而体外免疫原性的变化很小.

88 0
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2017-11-21 小铭的皮普

liaojiele

0 0
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2017-11-21 儒医liu

非常好!

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Kidney Int：增强干细胞在缺血再灌注肾损伤中功效的新方法！

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