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Arthritis Rheumatol:系统性红斑狼疮中的精神病

2018-11-05 xiangting MedSci原创

精神病是NPSLE的罕见表现。一般来说,它在SLE发病后的早期出现,对健康状况有显著的负面影响。

这项研究目的是在多种族/人种、前瞻性SLE初始队列中,确定狼疮精神病的风险、特征、与临床和自身抗体的关联,以及医生和患者评估的长短期结局。

每年对患者进行19项神经精神(NP)事件评估,其中包括精神病。收集SLE疾病活动性2000、SLICC/ACR损伤指数和SF-36评分。适当时使用时间事件和线性回归进行分析。

在1826例SLE患者中,88.8%为女性,48.8%为高加索人。年龄平均值±SD为35.1±13.3岁,病程5.6±4.2个月,随访时间为7.4±4.5年。28/1,826例患者(1.53%)出现31个精神病事件,大多数[(26/28;93%)]为单次事件。大多数患者[20/25;(80%)]和事件[28/31;(90%)]中,精神病是由SLE引起的,通常在SLE诊断的3年内。与狼疮精神病呈正相关的是[HR(95%CI)]既往SLE NP事件[3.59,(1.16,11.14)、男性[3.0,(1.20,7.50)]、SLE诊断时年龄较小[(每年轻10岁),1.45(1.01,2.07)]和非洲裔[4.59(1.79,11.76)]。通过医生评估,大多数的精神病事件在发病后第二次年度随访时得到解决,患者报告的SF‐36总评分和子量表评分同样也有改善。

精神病是NPSLE的罕见表现。一般来说,它在SLE发病后的早期出现,对健康状况有显著的负面影响。根据患者和医生的报告,大多数患者的短期和长期预后很好,但需要进行仔细的随访。

原始出处:
John G. Hanly.  Psychosis in Systemic Lupus Erythematosus. Arthritis Rheumatol. 30 October 2018.

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    2018-11-07 zhaojie88
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    2018-11-07 zhouqu_8

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