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Am J Resp Crit Care:MRI在肺动脉高压患者预后评价中的作用!

2017-03-23 xing.T MedSci原创

由此可见,反映了RV结构和近端肺血管系统的硬度的MRI指标是肺动脉高压患者的独立预测因素。结合临床数据,MRI对PAH患者预后评估的准确性适中。

预测在肺动脉高压(PAH)患者咨询和明确其治疗策略时是非常重要的。近日,呼吸内科领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,研究人员旨在明确MRI指标在PAH死亡率预测中的价值。

研究人员从ASPIRE肺动脉高压研究注册中纳入了连续就诊的接受MRI检查的肺动脉高压患者。在随访42个月(范围17-142)期间,研究人员分析了576例患者,221(38%)例患者发生死亡。推导队列(n=288,115人死亡)和验证队列(n=288,106人死亡)被确定。研究人员采用多变量Cox回归发现了2个独立的死亡预测因子(P<0.01);调整年龄和性别的右心室收缩末期容积指数(RVESVI%pred)与肺动脉相对面积的变化。

由推导队列构建的一个的MRI模型和临床资料在1年后预测验证队列的死亡率,其灵敏度为70(95%可信区间为53-83),特异性为62(95%可信区间为62-68)、阳性预测值(PPV)为24(95%可信区间为16-32)和阴性预测值(NPV)为92(95%可信区间为87-96),以及3年后,其灵敏度为77(95%可信区间为67-85)、特异性为73(95%可信区间为66-65)、PPV为56(95%可信区间为47-65)和NPV为87(95%可信区间为81-92)。该模型在3年后IPAH患者中更准确(敏感性为89(95%可信区间为65-84)、特异性为76(95%可信区间为65-84)、PPV为60(95%可信区间为46-74)和NPV为94(95%可信区间为85-98))。

由此可见,反映了RV结构和近端肺血管系统的硬度的MRI指标是肺动脉高压患者的独立预测因素。结合临床数据,MRI对PAH患者预后评估的准确性适中。

原始出处:

Andrew J Swift, et al. Magnetic Resonance Imaging in the Prognostic Evaluation of Patients with Pulmonary Arterial Hypertension. AM J RESP CRIT CARE 2017.http://dx.doi.org/10.1164/rccm.201611-2365OC

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    2017-03-25 huagfeg
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    2017-03-24 cqykthl

    RV结构和近端肺血管系统的硬度的MRI指标是肺动脉高压患者的独立预测因素

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