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Stroke:重新认识脑静脉血栓的发生率

2016-10-29 MedSci MedSci原创

背景:各研究中脑静脉血栓形成的发生率(CVT)不同,但是估计为每年百万人中2到5之间。最近的一项荷兰研究表明CVT的发生率要高于综合认定的发生率。这些不同的发病率的估计是否反映真正的变化尚不确定。本研究的目的是使用一种新的临床和影像学方法确定阿德莱德CVT的发生率。方法:研究者回顾性研究2005到2011年阿德莱德所有公立医院疾病国际分类编码确定的CVT。研究者还检索了这些医院诊断为静脉血栓患者的

背景:各研究中脑静脉血栓形成的发生率(CVT)不同,但是估计为每年百万人中2到5之间。最近的一项荷兰研究表明CVT的发生率要高于综合认定的发生率。这些不同的发病率的估计是否反映真正的变化尚不确定。本研究的目的是使用一种新的临床和影像学方法确定阿德莱德CVT的发生率。

方法:研究者回顾性研究2005到2011年阿德莱德所有公立医院疾病国际分类编码确定的CVT。研究者还检索了这些医院诊断为静脉血栓患者的所有的影像学研究(259 101)。回顾所有可能的病例,及确定CVT的病例。评估其相关性和预后。

结果:169例可能为CVT的病例中,确诊CVT的为105例(59根据诊断编码和神经影像学诊断、40仅根据神经影像学,6例仅根据诊断编码)。在953 390成人人口中,这代表每年的每百万人群的发生率为15.7(95%CI,12.9-19.0),为目前报道的最高发病率。这些病例中,48%被确定为促凝血倾向。55/105例为女性。生育年龄的女性CVT存在的相对风险显著高于男性(1.18 [ 95%CI,0.94-1.48 ])。

结论:研究结果表明,脑静脉窦血栓的发生率高于以往的报道,这也许是因为更确切的认定。未来CVT发病率的研究应该包括综合评估及神经影像学。

原始出处:

Devasagayam S, Wyatt B,et al. Cerebral Venous Sinus Thrombosis Incidence Is Higher Than Previously Thought: A Retrospective Population-Based Study. Stroke. 2016 Sep.


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    2017-02-22 fusion
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    2017-03-09 xue8602
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