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Stroke:肾功能障碍与脑卒中后出院和住院死亡率相关

2016-12-30 xing.T MedSci原创

入院时eGFR是卒中后短期预后的重要预测因子。

肾脏疾病是急性缺血性卒中患者常见的合并症。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在明确入院时估计的肾小球滤过率(eGFR)是否与卒中后住院死亡率或出院情况相关。

在这项队列研究中,研究人员对来自“Get With The Guidelines–Stroke ”项目相关医疗保险费用数据库中缺血性卒中患者的数据进行分析。研究人员采用肾脏病饮食改良(MDRD)方程来计算eGFR (mL/min/1.73 m2)。透析是根据国际疾病分类第9次修订码来进行定义。调整后的多变量Cox比例风险模型被用来确定eGFR与出院和住院死亡率之间的独立相关性。调整后的个人模型还评估了临床和人口学因素是否与不同eGFR水平的结局存在相关性。

在232236例患者中,47.3%的患者eGFR≥60,26.6%的患者eGFR在45-59之间,16.8%的患者eGFR在30-44之间,5.6%的患者eGFR在15-29之间,0.7%的患者eGFR<15但未进行透析治疗,2.8%的患者接受透析治疗。在整个队列中,有11.8%的患者在住院或被送到疗养院期间死亡,其中38.6%的患者出院。对其他相关变量进行调整后,肾功能障碍与住院死亡率风险增加独立相关,在那些eGFR<15但未进行透析治疗的患者中风险最高(比值比为2.52;95%可信区间为2.07-3.07)。eGFR为15-29(比值比为0.82;95%可信区间为0.78 - 0.87),eGFR<15(比值比为0.72;95%可信区间为0.61-0.86),透析(比值比为0.86;95%可信区间为0.79-0.94)仍与较低的出院回家可能性相关。此外,几个临床和人口学因素与不同eGFR水平的结局存在相关性。

由此可见,入院时eGFR是卒中后短期预后的重要预测因子。    

原始出处:

Nada El Husseini, et al. Renal Dysfunction Is Associated With Poststroke Discharge Disposition and In-Hospital Mortality Findings From Get With The Guidelines–Stroke. Stroke. December 29, 2016. 

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    2017-05-28 yese
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