J Clin Periodontol：先兆子痫或与牙周炎相关

2014-09-08 MedSci编译 MedSci原创

印度一项研究表明，先兆子痫或与牙周炎相关。这项研究聚焦于细胞因子在其中的作用。研究连续纳入504位怀孕14-18周的孕妇，测量血清 IL-4, IL-10, TNF-α, IFN-γ水平。研究表明，牙周炎怀孕女性血清TNF-α & IL-4的水平（对数值）分别为(4.13 ± 2.06; 0.47 ± 1.56 pg/ml ，而正常人群仅为2.16 ± 1.51; 0.

印度一项研究表明，先兆子痫或与牙周炎相关。这项研究聚焦于细胞因子在其中的作用。研究连续纳入504位怀孕14-18周的孕妇，测量血清 IL-4, IL-10, TNF-α, IFN-γ水平。研究表明，牙周炎怀孕女性血清TNF-α & IL-4的水平（对数值）分别为(4.13 ± 2.06; 0.47 ± 1.56 pg/ml ，而正常人群仅为2.16 ± 1.51; 0.02 ± 1.84 pg/m，二者有显著性差异（p < 0.001）。牙周围疾病与血清 TNF-α的对数值密切相关，如果取cutoff值为14.43 pg/ml时，敏感性为71.2%，特异性为62% (OR = 4.04; 95%CI = 2.77-5.87)。

女性有牙周疾病，当TNF-α (3.72 ± 1.33 pg/ml)水平时容易发现先兆子痫，而在(4.20 ± 2.15 pg/ml, p ≥ 0.05)时不易发生，但尚未观察到统计学差异。这项研究初步表明，在第二孕周时，血清TNF-α 与先兆子痫可能有关。

另外，在2013年Sgolastra F发表一项meta分析荟萃了15项研究（3项队列，12项病例对照研究）发现，牙周炎与先兆子痫的风险增加有关(OR 2.17, 95% CI 1.38-3.41, P = 0.0008)，但同时也发现研究的异质性很强。新近一项韩国研究认为不吸烟人群中，牙周炎与先兆子痫的风险增加有关。

MedSci启示：其实不仅仅是先兆子痫，目前发现大量疾病可能均与牙周炎有关。牙周炎可能只是机体普遍存在炎症的缩影。如冠心病，也认为与牙周炎有关，牙周炎患者，冠心病的风险会增加；那么肾病，肝病，肺部疾病，卒中......这些疾病与牙周炎是否也存在千丝万缕的联系？这些细节需要我们临床研究者细心观察，能洞察其它研究者不能发现的内容，这就是创新！

原始出处：

Kumar A, Begum N, Prasad S, Lamba AK, Verma M, Agarwal S, Sharma S.Role of cytokines in development of pre-eclampsia associated with periodontal disease - Cohort Study. J Clin Periodontol. 2014 Apr;41(4):357-65

相关文献：

Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A.Relationship between periodontitis and pre-eclampsia: a meta-analysis. PLoS One. 2013 Aug 19;8(8):e71387.

Pattanashetti JI, Nagathan VM, Rao SM.Evaluation of Periodontitis as a Risk for Preterm Birth among Preeclamptic and Non-Preeclamptic Pregnant Women - A Case Control Study. J Clin Diagn Res. 2013 Aug;7(8):1776-8.

Ha JE, Jun JK, Ko HJ, Paik DI, Bae KH.Association between periodontitis and preeclampsia in never-smokers: a prospective study. J Clin Periodontol. 2014 Sep;41(9):869-74.

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2017-05-10 laymankey

感谢分享一下！！！

73 0
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2015-01-08 feather89

#PE#

54 0
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2014-09-10 liuyong2982

#牙周#

51 0
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2014-09-08 175.0.130.187

启示写得好

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