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Sleep:65岁以下睡眠呼吸暂停综合症患者的左心功能较差

2016-03-13 QQduhp 译 MedSci原创

目的阻塞性睡眠呼吸暂停(OSA)的存在和严重性与左心室(LV)结构和功能受损有关。该研究的目的是在在一个种族多样化的群体中量化LV收缩功能和结构与阻塞性睡眠呼吸暂停综合症严重程度之间的关系,并评估年龄和性别差异对其关系的影响。 方法 研究人员对1412名参与者(来自6个美国多种族社区)进行了横断面研究和数据分析。参与者于2010-2012年接受了夜间多导睡眠图和心脏磁共振成像。研究人员通过调整身高

目的:阻塞性睡眠呼吸暂停(OSA)的存在及其严重性与左心室(LV)结构和功能受损有关。该研究的目的是在一个种族多样化的群体中量化LV收缩功能和结构与阻塞性睡眠呼吸暂停综合症严重程度之间的关系,并评估年龄和性别差异对其关系的影响。

 
方法:研究人员对1412名参与者(来自6个美国多种族社区)进行了横断面研究和数据分析。参与者于2010-2012年接受了夜间多导睡眠图和心脏磁共振成像。研究人员通过调整身高、LV质量/体积比、LV射血分数后评估阻塞性通气指数(AHI)的临床类别分型(<5,5-15,15-30,30-50,> 50)和参与者LV之间的关系。

结果:在调整了潜在的混杂因素后,研究人员发现,年龄小于65岁且AHI增加的参与者LV质量显著增加(β=1.84±0.47g/m,P = 0.0001)。相比黑人和西班牙裔民众而言,白人和中国人AHI与LV质量之间的关系更为密切,虽然LV质量和质量/体积比与睡眠呼吸暂停明显相关,但左心射血分数与阻塞性睡眠呼吸暂停综合症的严重程度无关。且在这方面男女没有明显差异。 

结论:调整混杂因素后,研究人员发现,65岁以下的男性和女性,AHI越高则其LV质量明显增加。

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    2016-03-22 1de304d2m86(暂无匿称)

    学习了解了

    0

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