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JAHA:急性自发性脑出血患者血清镁水平与预后之间的关系!

2018-04-13 xing.T MedSci原创

由此可见,急性自发性ICH患者入院时较高的镁离子水平与较低的入院血肿体积和入院ICH评分有关。

镁离子具有潜在的止血性能。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员试图明确急性自发性脑出血(ICH)患者血清中镁离子水平(基线和48小时)与预后之间潜在的联系。

研究人员回顾了所有自发性ICH患者在基线和5年后镁离子水平的数据。临床和影像学结局指标包括初始血肿体积、入院NIHSS量表得分和ICH评分、住院死亡率、良好的功能结局(改良Rankin量表评分为0–1分)和出院时功能独立性(改良Rankin量表评分为0–2分)。

研究对象为299例ICH患者(平均年龄为61-13岁,平均入院血清镁离子水平为1.8±0.3mg/dL)。研究人员发现增加的镁离子水平与入院时较低的NIHSS量表得分(Spearman检验r为−0.141;P=0.015)、较低ICH评分(Spearman检验r为−0.153;P=0.009)和较小的初始血肿体积(Spearman检验r为−0.153;P=0.012)密切相关。出院时功能结局1.9±0.3 vs. 1.8±0.3 mg/dL; P=0.025)和功能独立性(1.9±0.3 vs. 1.8±0.3 mg/dL; P=0.022) 良好的患者入院时镁离子水平较高。48小时血清镁水平与任何结局变量之间无关联。多元线性回归分析发现,入院时血清镁含量每增加0.1mg/dL与入院时血肿体积(回归系数为−0.020;95%可信区间为−0.040至0;P=0.049)和住院ICH评分(回归系数为−0.053;95%可信区间为−0.102至−0.005;P=0.032)呈负相关。

由此可见,急性自发性ICH患者入院时较高的镁离子水平与较低的入院血肿体积和入院ICH评分有关。

原始出处:

Nitin Goyal,et al. Serum Magnesium Levels and Outcomes in Patients With Acute Spontaneous Intracerebral Hemorrhage, JAHA.2018. https://doi.org/10.1161/JAHA.118.008698

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    2018-04-18 1222becem95暂无昵称

    谢谢分享

    0

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    2018-04-15 大爰

    学习了谢谢分享!!

    0

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    2018-04-15 zhaohui6731
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    2018-04-15 sodoo
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    2018-04-14 雅文博武

    学习了很多先进的医学知识

    0

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    2018-04-14 yfjms

    学习

    0

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    2018-04-13 天地飞扬

    了解一下.谢谢分享!

    0

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    2018-04-13 医者仁心5538

    学习了

    0

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