JAMA Pediatr：极早产儿的氧气饱和度目标范围

2015-02-13 赵洲译 MedSci原创

极早产儿的氧气饱和度（SpO2）的最理想的目标范围至今未知。JAMA Pediatrics近日刊发综述文章，对极早产儿的氧气饱和度相关研究进行系统性介绍和meta分析。本文的旨在于系统性地综述评价极早产儿暴露在限制性或非限制性的氧气饱和度的情况下对发病率和死亡率的影响的证据。数据资源来自于MEDLINE，PubMed，CENTRAL，和CINAHL数据库自创建以来至2014年3月31日的全部相

极早产儿的氧气饱和度（SpO2）的最理想的目标范围至今未知。JAMA Pediatrics近日刊发综述文章，对极早产儿的氧气饱和度相关研究进行系统性介绍和meta分析。本文的旨在于系统性地综述评价极早产儿暴露在限制性或非限制性的氧气饱和度的情况下对发病率和死亡率的影响的证据。

数据资源来自于MEDLINE，PubMed，CENTRAL，和CINAHL数据库自创建以来至2014年3月31日的全部相关论文以及2000年至2014年间提交至儿科学学会所以摘要。所有已经发表的随机试验均是评价氧气饱和度对极早产儿的影响。限制性氧气饱和度为85%-89%，非限制性则为91%-95%。婴儿则是妊娠期不足28周的极早产儿。所有的meta分析均由Review Manager5.2得出结果。Cochrane偏差风险工具用于评价此项研究的质量。使用GRADEpro对调查结果总结和效果预估的可信度进行评价。随机效应模型被用来评价治疗效果。此项研究关注的结果主要包括极早产儿在出院前死亡，2岁前死亡或严重残疾，2岁前死亡，神经发育的结果，听力丧失，支气管肺部发育不良，坏死性小肠结肠炎以及严重的早产儿视网膜病。

分析数据得知，2岁前的死亡或残疾的结果并未差异（危险比1.02，95%置信区间0.92-1.14）。2岁前的死亡率也无差异（危险比1.13,95%CI0.97-1.13）。但限制组的出院前死亡率有明显的上升。限制组的坏死性小肠结肠炎发病率也更高。通过多项GRADE评价，研究人员认为这些结果的证据质量处于中等偏低。

这一综述将对极早产儿的氧气饱和度的选择有着积极的指导意义。

原始出处

Manja V, Lakshminrusimha S, Cook DJ. Oxygen Saturation Target Range for Extremely Preterm Infants: A Systematic Review and Meta-analysis. JAMA Pediatr.Published online February 09, 2015. doi:10.1001/jamapediatrics.2014.3307.

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2015-10-15 feather89

#PE#

59 0
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2015-08-07 ms9608593228839890

#DIA#

46 0
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2015-03-05 happypig

东西不错。可以多学习。

198 0
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2015-02-16 Johnny1989

赞

186 0
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2015-02-16 Johnny1989

谢谢分享！

136 0
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2015-02-16 windmilL1989

小编评论亮了

132 0
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2015-02-15 wmr113

#极早产儿#

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