Clinica Chimica Acta：2型糖尿病患者血清脂肪细胞脂肪酸结合蛋白浓度较高与主动脉硬化增加有关

2019-09-16 Gladiator MedSci原创

脂肪细胞脂肪酸结合蛋白<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family:宋体;mso-bidi-font-family:"Times New

脂肪细胞脂肪酸结合蛋白(a - fabp)是一种新型的脂肪因子，可引起代谢紊乱、2型糖尿病(T2DM)和动脉粥样硬化。本研究探讨了2型糖尿病患者血清A-FABP与主动脉硬化的相关性。

研究人员通过收集156例2型糖尿病患者的空腹血样，采用酶免疫法测定血清a - fabp浓度。使用SphygmoCor系统测量颈动脉 - 股动脉脉搏波速度（cfPWV），并且将cfPWV值> 10m / s定义为高主动脉僵硬。

研究结果显示60名参与者(38.4%)属于高主动脉僵硬组。与对照组相比，该组显示年龄较大（P = .004），收缩压较高（P <.001），舒张压（P = .027），尿白蛋白与肌酐比值（P = .003），血清A-FABP（P <.001）和较低的估计肾小球滤过率（P = .001）。在使用多变量逻辑回归分析调整与主动脉僵硬度显著相关的因素后，发现血清A-FABP [OR = 1.029（1.002-1.058），P = .039]是T2DM患者主动脉僵硬度的独立预测因子。

研究表明，T2DM患者血清A-FABP水平与主动脉硬化呈正相关。

原始出处：

Pei-Wei Tseng，Jia-Sian Hou，High serum adipocyte fatty acid binding protein concentration linked with increased aortic arterial stiffness in patients with type 2 diabetes

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2019-12-12 windight

#CTA#

75 0
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2020-02-19 HNYYM

#主动脉硬化#

57 0
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2019-09-18 aids213

#2型糖尿病患者#

51 0
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2019-09-18 shenxlcyp

#脂肪细胞#

0 0
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2019-09-18 circumcision

#主动脉#

52 0
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2019-09-18 xue8604

#糖尿病患者#

43 0
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2019-09-18 12498974m55暂无昵称

#浓度#

53 0
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2019-09-16 misszhang

谢谢MedSci提供最新的资讯

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